In other species: dog , taurine cattle

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606152 (gene) , 607483 (trait)

Single-gene trait/disorder: unknown

Disease-related: yes

Cross-species summary: Also known as juvenile-onset necrotizing/necrotising encephalopathy (SNE)

Species summary: Frizziero et al. (2026) report a a six-month-old Maine Coon crossbred kitten with selective symmetrical encephalomalacia with a fatal outcome. "The clinical and neuropathological findings showed important similarities with Leigh-like encephalopathies ... ." 

Species-specific name: Selective symmetrical encephalomalacia

Breed: Maine Coon (Cat) (VBO_0100154).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).