In other species: rock pigeon , chicken , common canary

Categories: Pigmentation phene

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal co-dominant

Disease-related: no

Key variant known: yes

Year key variant first reported: 2020

Molecular basis: Xi et al. (2020) identified "a 14-bp insertion (NW_013185915.1: g. 750,748–750,735 insertion. CACAGGTGAGCTCT) in exon 3 of EDNRB2 . . . [that] was homozygous in all the white geese we detected and heterozygous in gray geese, indicating that this mutation is recessive. Furthermore, this 14-bp insertion leads to a frameshift mutation in the EDNRB2 coding region and nonsense-mediated mRNA decay." Yang et al. (2024) report that "the gray plumage color was codominant to the white color in [Wugangtong] WGT geese, and plumage color variations were controlled by EDNRB2. ... Sanger sequencing of the region surrounding the EDNRB2 gene identified a 14-bp insertion within exon 3 [previously reported by Xi et al. 2020] as the causal mutation. The heterozygosity of this 14-bp insertion and wild-type alleles was completely associated with the Wb phenotype [grey with white breast circle], thereby substantiating the codominant nature of the G [solid grey] and W [white] phenotypes."

Breeds: Gang, China (Goose (domestic)) (VBO_0009987), Wugang Copper, China (Goose (domestic)) (VBO_0009999).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Associated gene: