OMIA 001276-9940 : Facial eczema in Ovis aries

In other species: cattle

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: Morris et al. (1995) reported a heritability of 45% for liability to this disease.

Markers: By genotyping sheep from lines selected for resistance and susceptibility to facial eczema (FE) with the Illumina OvineSNP50 BeadChip (yielding 50,975 informative SNPs), Phua et al. (2014; Anim Genet 45:240-7) identified "at least eight genomic regions that underwent a selection sweep in the FE lines". In a subsequent paper, Phua et al. (2014; Anim Genet: early view) reported the development of "a genome-enabled prediction approach to screen for FE-tolerant sheep", based on genotypes from the Illumina OvineSNP50 BeadChip, providing "genomic prediction for FE . . . for the Romney breed [with] . . . an accuracy of 0.38".

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2014 Phua, S.H., Brauning, R., Baird, H.J., Dodds, K.G. :
Identifying chromosomal selection-sweep regions in facial eczema selection-line animals using an ovine 50K-SNP array. Anim Genet 45:240-7, 2014. Pubmed reference: 24521158. DOI: 10.1111/age.12122.
Phua, S.H., Hyndman, D.L., Baird, H.J., Auvray, B., McEwan, J.C., Lee, M.A., Dodds, K.G. :
Towards genomic selection for facial eczema disease tolerance in the New Zealand sheep industry. Anim Genet :, 2014. Pubmed reference: 24804852. DOI: 10.1111/age.12167.
2011 Phua, S.H., Dodds, K.G. :
Different methods detected different loci involved in resistance to facial eczema disease of sheep. Proceedings of the Association for the Advancement of Animal Breeding and Genetics 19:171-174, 2011.
2009 Phua, SH., Dodds, KG., Morris, CA., Henry, HM., Beattie, AE., Garmonsway, HG., Towers, NR., Crawford, AM. :
A genome-screen experiment to detect quantitative trait loci affecting resistance to facial eczema disease in sheep. Anim Genet 40:73-9, 2009. Pubmed reference: 19032699. DOI: 10.1111/j.1365-2052.2008.01803.x.
2007 Duncan, EJ., Dodds, KG., Henry, HM., Thompson, MP., Phua, SH. :
Cloning, mapping and association studies of the ovine ABCG2 gene with facial eczema disease in sheep. Anim Genet 38:126-31, 2007. Pubmed reference: 17403009. DOI: 10.1111/j.1365-2052.2006.01557.x.
2004 Morris, CA., Towers, NR., Hohenboken, WD., Maqbool, N., Smith, BL., Phua, SH. :
Inheritance of resistance to facial eczema: a review of research findings from sheep and cattle in New Zealand. N Z Vet J 52:205-15, 2004. Pubmed reference: 15768115. DOI: 10.1080/00480169.2004.36431.
2002 Morris, CA., Smith, BL., Hickey, SM. :
Relationship between sporidesmin-induced liver injury and serum activity of gamma-glutamyltransferase in Romney lambs sired by facial eczema-resistant or control rams. N Z Vet J 50:14-8, 2002. Pubmed reference: 16032203. DOI: 10.1080/00480169.2002.36243.
2001 Morris, C.A., Wesselink, C., Wilson, J.A., DeNicolo, G., Towers, N.R. :
Susceptibility to facial eczema in lambs sired by East Friesian, Romney Control, and Romney facial eczema resistant rams New Zealand Journal of Agricultural Research 44:47-52, 2001.
1999 Morris, C.A., Amyes, N.C., Towers, N.R., Wesselink, C. :
Correlated responses to selection for or against facial eczema susceptibility in Romney sheep in New Zealand New Zealand Journal of Agricultural Research 42:475-481, 1999.
Phua, S.H., Dodds, K.G., Morris, C.A., Paterson, K.A., McEwan, J.C., Garmonsway, H.G., Towers, N.R., Crawford, A.M. :
Catalase gene is associated with facial eczema disease resistance in sheep Animal Genetics 30:286-295, 1999. Pubmed reference: 10467703.
1995 Morris, C.A., Towers, N.R., Wheeler, M., Wesselink, C. :
Selection for or against facial eczema susceptibility in Romney sheep, as monitored by serum concentrations of a liver enzyme New Zealand Journal of Agricultural Research 38:211-219, 1995.
1994 Briggs, L.R., Towers, N.R., Molan, P.C. :
Development of an enzyme-linked immunosorbent assay for analysis of sporidesmin A and its metabolites in ovine urine and bile Journal of Agricultural and Food Chemistry 42:2769-2777, 1994.
1993 Munday, R., Pearson, A., Ferguson, L.R. :
Mouse Micronucleus Assays of Sporidesmin, the Toxin Associated with Facial Eczema in Ruminants Mutation Research 302:71-74, 1993. Pubmed reference: 7683110.
1991 Morris, C.A., Towers, N.R., Wesselink, C., Southey, B.R. :
Effects of Facial Eczema on Ewe Reproduction and Postnatal Lamb Survival in Romney Sheep New Zealand Journal of Agricultural Research 34:407-412, 1991.
1989 Morris, C.A., Towers, N.R., Campbell, A.G., Meyer, H.H., Wesselink, C., Wheeler, M. :
Responses Achieved in Romney Flocks Selected for or Against Susceptibility to Facial Eczema, 1975-87 New Zealand Journal of Agricultural Research 32:379-388, 1989.
1986 Loong, P.C., Jordan, T.W., Wheeler, T.T., Ford, H.C., Campbell, A.G. :
Use of two-dimensional polyacrylamide gel electrophoresis to detect plasma protein variation between Romney sheep selected for facial eczema resistance or susceptibility New Zealand Journal of Agricultural Research 29:449-456, 1986.

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  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 12 May 2014