OMIA:001276-9940 : Facial eczema in Ovis aries (sheep)

In other species: taurine cattle

Categories: Integument (skin) phene

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: Morris et al. (1995) reported a heritability of 45% for liability to this disease.

Markers: By genotyping sheep from lines selected for resistance and susceptibility to facial eczema (FE) with the Illumina OvineSNP50 BeadChip (yielding 50,975 informative SNPs), Phua et al. (2014; Anim Genet 45:240-7) identified "at least eight genomic regions that underwent a selection sweep in the FE lines". In a subsequent paper, Phua et al. (2014; Anim Genet 45: 559-64) reported the development of "a genome-enabled prediction approach to screen for FE-tolerant sheep", based on genotypes from the Illumina OvineSNP50 BeadChip, providing "genomic prediction for FE . . . for the Romney breed [with] . . . an accuracy of 0.38". From a GWAS on 2669 sheep, "genotyped with either the Ovine Infinium® HD SNP BeadChip (n=137 animals; 606,006 makers; “HD”) or the Illumina OvineSNP50 BeadChip (n=2532 animals; 53,903 markers; “50K”)", McRae et al. (2021) identified "Two regions on chromosomes 15 and 24 . . . which explain 5% and 1% of the phenotypic variance in the response to FE [Facial Eczema], respectively. The region on chromosome 15 contains the β‐globin locus. Of the significant SNPs in the region, one is a missense variant within the haemoglobin subunit β (HBB) gene."

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001276-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 McRae, K.M., Rowe, S.J., Johnson, P.L., Baird, H.J., Cullen, N.G., Bixley, M.J., Plowman, J.E., Deb-Choudhury, S., Brauning, R., Amyes, N.C., Dodds, K.G., Newman, S.N., McEwan, J.C., Clarke, S.M. :
Genomic tools for the identification of loci associated with facial eczema in New Zealand sheep. Genes (Basel) 12:1560, 2021. Pubmed reference: 34680955. DOI: 10.3390/genes12101560.
2014 Phua, S.H., Hyndman, D.L., Baird, H.J., Auvray, B., McEwan, J.C., Lee, M.A., Dodds, K.G. :
Towards genomic selection for facial eczema disease tolerance in the New Zealand sheep industry. Anim Genet 45:559-564, 2014. Pubmed reference: 24804852. DOI: 10.1111/age.12167.
Phua, S.H., Brauning, R., Baird, H.J., Dodds, K.G. :
Identifying chromosomal selection-sweep regions in facial eczema selection-line animals using an ovine 50K-SNP array. Anim Genet 45:240-7, 2014. Pubmed reference: 24521158. DOI: 10.1111/age.12122.
2013 Morris, C.A., Phua, S.H., Cullen, N.G., Towers, N.R. :
Review of genetic studies of susceptibility to facial eczema in sheep and dairy cattle. New Zealand Journal of Agricultural Research 56:156-170, 2013. DOI: 10.1080/00288233.2012.757240.
2011 Phua, S.H., Dodds, K.G. :
Different methods detected different loci involved in resistance to facial eczema disease of sheep. Proceedings of the Association for the Advancement of Animal Breeding and Genetics 19:171-174, 2011.
2009 Phua, SH., Dodds, KG., Morris, CA., Henry, HM., Beattie, AE., Garmonsway, HG., Towers, NR., Crawford, AM. :
A genome-screen experiment to detect quantitative trait loci affecting resistance to facial eczema disease in sheep. Anim Genet 40:73-9, 2009. Pubmed reference: 19032699. DOI: 10.1111/j.1365-2052.2008.01803.x.
2007 Duncan, EJ., Dodds, KG., Henry, HM., Thompson, MP., Phua, SH. :
Cloning, mapping and association studies of the ovine ABCG2 gene with facial eczema disease in sheep. Anim Genet 38:126-31, 2007. Pubmed reference: 17403009. DOI: 10.1111/j.1365-2052.2006.01557.x.
2004 Morris, CA., Towers, NR., Hohenboken, WD., Maqbool, N., Smith, BL., Phua, SH. :
Inheritance of resistance to facial eczema: a review of research findings from sheep and cattle in New Zealand. N Z Vet J 52:205-15, 2004. Pubmed reference: 15768115. DOI: 10.1080/00480169.2004.36431.
2002 Morris, CA., Smith, BL., Hickey, SM. :
Relationship between sporidesmin-induced liver injury and serum activity of gamma-glutamyltransferase in Romney lambs sired by facial eczema-resistant or control rams. N Z Vet J 50:14-8, 2002. Pubmed reference: 16032203. DOI: 10.1080/00480169.2002.36243.
2001 Morris, C.A., Wesselink, C., Wilson, J.A., DeNicolo, G., Towers, N.R. :
Susceptibility to facial eczema in lambs sired by East Friesian, Romney Control, and Romney facial eczema resistant rams New Zealand Journal of Agricultural Research 44:47-52, 2001.
1999 Morris, C.A., Amyes, N.C., Towers, N.R., Wesselink, C. :
Correlated responses to selection for or against facial eczema susceptibility in Romney sheep in New Zealand New Zealand Journal of Agricultural Research 42:475-481, 1999.
Phua, S.H., Dodds, K.G., Morris, C.A., Paterson, K.A., McEwan, J.C., Garmonsway, H.G., Towers, N.R., Crawford, A.M. :
Catalase gene is associated with facial eczema disease resistance in sheep Animal Genetics 30:286-295, 1999. Pubmed reference: 10467703.
1995 Morris, C.A., Towers, N.R., Wheeler, M., Wesselink, C. :
Selection for or against facial eczema susceptibility in Romney sheep, as monitored by serum concentrations of a liver enzyme New Zealand Journal of Agricultural Research 38:211-219, 1995.
1994 Briggs, L.R., Towers, N.R., Molan, P.C. :
Development of an enzyme-linked immunosorbent assay for analysis of sporidesmin A and its metabolites in ovine urine and bile Journal of Agricultural and Food Chemistry 42:2769-2777, 1994.
1993 Munday, R., Pearson, A., Ferguson, L.R. :
Mouse Micronucleus Assays of Sporidesmin, the Toxin Associated with Facial Eczema in Ruminants Mutation Research 302:71-74, 1993. Pubmed reference: 7683110.
1991 Morris, C.A., Towers, N.R., Wesselink, C., Southey, B.R. :
Effects of Facial Eczema on Ewe Reproduction and Postnatal Lamb Survival in Romney Sheep New Zealand Journal of Agricultural Research 34:407-412, 1991.
1989 Morris, C.A., Towers, N.R., Campbell, A.G., Meyer, H.H., Wesselink, C., Wheeler, M. :
Responses Achieved in Romney Flocks Selected for or Against Susceptibility to Facial Eczema, 1975-87 New Zealand Journal of Agricultural Research 32:379-388, 1989.
1986 Loong, P.C., Jordan, T.W., Wheeler, T.T., Ford, H.C., Campbell, A.G. :
Use of two-dimensional polyacrylamide gel electrophoresis to detect plasma protein variation between Romney sheep selected for facial eczema resistance or susceptibility New Zealand Journal of Agricultural Research 29:449-456, 1986.
1942 Cunningham, I.J., Hopkirk, C.S.M., Filmer, J.F. :
Photosensitivity diseases in New Zealand. 1. Facial eczema: its clinical, pathological, and biochemical characterization. N Z J Sci Technol A 24:185–198, 1942.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 12 May 2014
  • Changed by Frank Nicholas on 10 Oct 2021
  • Changed by Imke Tammen2 on 19 Aug 2023