OMIA:001325-9615 : Protein-losing enteropathy in Canis lupus familiaris (dog)

Categories: Digestive / alimentary phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: A GWAS conducted by Donnini et al. (2020) on "106 related Gordon setters was used, including 6 affected dogs from an affected litter, 6 case controls from the same litter, 10 related/affected dogs, and 84 related/unaffected dogs" revealed regions on six chromosomes contributing to variation in liability, consistent with multifactorial inheritance.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Soft Coated Wheaten Terrier (Dog) (VBO_0201260).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001325-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Myers, M., Martinez, S.A., Shiroma, J.T., Watson, A.T., Hostutler, R.A. :
Prospective evaluation of low-fat diet monotherapy in dogs with presumptive protein-losing enteropathy. J Am Anim Hosp Assoc 59:74-84, 2023. Pubmed reference: 36853920. DOI: 10.5326/JAAHA-MS-7248.
2021 Donnini, E.K., Walugembe, M., Rothschild, M.F., Jergens, A.E., Allenspach, K. :
An initial genome-wide investigation of protein-losing enteropathy in Gordon setters: Exploratory observations. Can J Vet Res 85:51-60, 2021. Pubmed reference: 33390653.
2020 Nagata, N., Ohta, H., Yokoyama, N., Teoh, Y.B., Nisa, K., Sasaki, N., Osuga, T., Morishita, K., Takiguchi, M. :
Clinical characteristics of dogs with food-responsive protein-losing enteropathy. J Vet Intern Med 34:659-668, 2020. Pubmed reference: 32060974. DOI: 10.1111/jvim.15720.
2016 Jacinto, A.M., Ridyard, A.E., Aroch, I., Watson, P.J., Morrison, L.R., Chandler, M.L., Acvim, D., Kuzi, S. :
Thromboembolism in dogs with protein-losing enteropathy with non-neoplastic chronic small intestinal disease. J Am Anim Hosp Assoc 53:185-192, 2016. Pubmed reference: 27841681. DOI: 10.5326/JAAHA-MS-6328.
2015 Nakashima, K., Hiyoshi, S., Ohno, K., Uchida, K., Goto-Koshino, Y., Maeda, S., Mizutani, N., Takeuchi, A., Tsujimoto, H. :
Prognostic factors in dogs with protein-losing enteropathy. Vet J 205:28-32, 2015. Pubmed reference: 26025135. DOI: 10.1016/j.tvjl.2015.05.001.
Whitehead, J., Quimby, J., Bayliss, D. :
Seizures associated with hypocalcemia in a Yorkshire terrier with protein-losing enteropathy. J Am Anim Hosp Assoc 51:380-4, 2015. Pubmed reference: 26535456. DOI: 10.5326/JAAHA-MS-6205.
2013 Vaden, S.L., Littman, M.P., Cianciolo, R.E. :
Familial renal disease in soft-coated wheaten terriers. J Vet Emerg Crit Care (San Antonio) 23:174-83, 2013. Pubmed reference: 23461660. DOI: 10.1111/vec.12027.
2000 Littman, M.P., Dambach, D.M., Vaden, S.L., Giger, U. :
Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997) Journal of Veterinary Internal Medicine 14:68-80, 2000. Pubmed reference: 10668820.
Vaden, S.L., Hammerberg, B., Davenport, D.J., Orton, S.M., Trogdon, M.M., Melgarejo, L.T., VanCamp, S.D., Williams, D.A. :
Food hypersensitivity reactions in Soft Coated Wheaten Terriers with protein-losing enteropathy or protein-losing nephropathy or both: Gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E Journal of Veterinary Internal Medicine 14:60-67, 2000. Pubmed reference: 10668819.
Vaden, S.L., Sellon, R.K., Melgarejo, L.T., Williams, D.A., Trogdon, M.M., VanCamp, S.D., Argenzio, R.A. :
Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both American Journal of Veterinary Research 61:518-524, 2000. Pubmed reference: 10803646.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 06 Jan 2021