OMIA 001469-9913 : Coat colour, white belt in Bos taurus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TWIST2||twist family bHLH transcription factor 2||Bos taurus||3||NC_037330.1 (118051375..118103634)||TWIST2||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Belted Galloway Brown Swiss Dutch Belted||Coat colour, white belt||TWIST2||repeat variation||"The belt-associated variant was a copy number variant (CNV) involving the quadruplication of a 6 kb non-coding sequence located approximately 16 kb upstream of the TWIST2 gene"||2017||28658273|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2017||Awasthi Mishra, N., Drögemüller, C., Jagannathan, V., Keller, I., Wüthrich, D., Bruggmann, R., Beck, J., Schütz, E., Brenig, B., Demmel, S., Moser, S., Signer-Hasler, H., Pieńkowska-Schelling, A., Schelling, C., Sande, M., Rongen, R., Rieder, S., Kelsh, R.N., Mercader, N., Leeb, T. :|
|A structural variant in the 5'-flanking region of the TWIST2 gene affects melanocyte development in belted cattle. PLoS One 12:e0180170, 2017. Pubmed reference: 28658273. DOI: 10.1371/journal.pone.0180170.|
|2016||Leroy, G., Besbes, B., Boettcher, P., Hoffmann, I., Capitan, A., Baumung, R. :|
|Rare phenotypes in domestic animals: unique resources for multiple applications. Anim Genet 47:141-53, 2016. Pubmed reference: 26662214. DOI: 10.1111/age.12393.|
|2010||Drogemuller, C., Demmel, S., Engensteiner, M., Rieder, S., Leeb, T. :|
|A shared 336 kb haplotype associated with the belt pattern in three divergent cattle breeds. Anim Genet 41:304-307, 2010. Pubmed reference: 19917047. DOI: 10.1111/j.1365-2052.2009.01987.x.|
|2009||Drögemüller, C., Engensteiner, M., Moser, S., Rieder, S., Leeb, T. :|
|Genetic mapping of the belt pattern in Brown Swiss cattle to BTA3. Anim Genet 40:225-9, 2009. Pubmed reference: 19159407. DOI: 10.1111/j.1365-2052.2008.01826.x.|
|1921||Durham, G.B. :|
|Inheritance of belting spotting in cattle and swine. American Naturalist 55:476-477, 1921.|
|1920||Kuiper, K. :|
|Onderzoekingen over kleur en teekening bij runderen [Research on color and colour patterns in cattle] Genetica 2:137-161, 1920.|
- Created by Frank Nicholas on 25 Feb 2010
- Changed by Frank Nicholas on 30 Jun 2017
- Changed by Frank Nicholas on 01 Jul 2017
- Changed by Tosso Leeb on 04 Jul 2017