OMIA 001546-9031 : Diplopodia-1 in Gallus gallus

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: no

Species-specific symbol: dp-1

Mapping: Robb et al. (2011) mapped this trait to chromosome GGA 1 (189,805,428 - 190,525,761)

Clinical features: "Homozygotes (-/-) display moderate preaxial polydactly, dwarfing, some with exposed vicscera, occasional cleft palate, and shortened upper beak" Robb et al. (2011)


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2012 Robb, E.A., Delany, M.E. :
Case study of sequence capture enrichment technology: identification of variation underpinning developmental syndromes in an amniote model. Genes (Basel) 3:233-47, 2012. Pubmed reference: 24704915. DOI: 10.3390/genes3020233.
2011 Robb, EA., Gitter, CL., Cheng, HH., Delany, ME. :
Chromosomal mapping and candidate gene discovery of chicken developmental mutants and genome-wide variation analysis of MHC congenics. J Hered 102:141-56, 2011. Pubmed reference: 21273214. DOI: 10.1093/jhered/esq122.
1996 Rodriguez, C., Kos, R., Macias, D., Abbott, U.K., Belmonte, J.C.I. :
Shh, hoxd, BMP-2, and FGF-4 gene expression during development of the polydactylous Talpid(2), Diplopodia(1), and Diplopodia(4) mutant chick limb buds Developmental Genetics 19:26-32, 1996. Pubmed reference: 8792606. DOI: 10.1002/(SICI)1520-6408(1996)19:1<26::AID-DVG3>3.0.CO;2-2.
1974 MacCabe, J.A., Abbott, U.K. :
Polarizing and maintenance activities in 2 polydactylous mutants of fowl: diplopodia-1 and talpid-2 Journal of Embryology and Experimental Morphology 31:735-746, 1974.
Taylor, LW. :
Further studies on diplopodia. VI. Segregation of diplopod embryos from chickens heterozygous for both dp-1 and dp-3 genes. Can J Genet Cytol 16:121-35, 1974. Pubmed reference: 4407166.
1959 Abbott, U.K. :
Further studies on diplopodia. III. The relationship between expressivity and penetrance in selected lines and crosses Journal of Genetics 56:197-225, 1959.
Abbott, U.K. :
Further studies on diplopodia. II. Embryological features Journal of Genetics 56:179-196, 1959.
Taylor, L.W., Abbott, U.K., Gunns, C.A. :
Further studies on diplopodia 1. Modification of phenotypic segregation ratios by selection Journal of Genetics 56:161-178, 1959.
1958 Abbott, U.K. :
Further studies on Diplopodia IV: Breeding performance of a presumably homozygous diplopod male. Proceedings. 10th int. Congr. Genet. 2:290-291, 1958.
1947 Taylor, LW., Gunns, CA. :
Diplopodia; a lethal form of polydactyly in chickens. J Hered 38:67-76, 1947. Pubmed reference: 20296125.

Edit History

  • Created by Frank Nicholas on 25 Feb 2011
  • Changed by Frank Nicholas on 17 Oct 2011