OMIA:001570-9615 : Persistent right aortic arch, with subclavian artery and ligamentum arteriosum in Canis lupus familiaris (dog)
Categories: Cardiovascular system phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Considered a defect: yes
Key variant known: no
Species-specific symbol: PRAA-SA-LA
Mapping: Using a comparative mapping strategy, Philipp et al. (2011) genotyped 7 affected and 58 control German Pinschers for 38 microsatellites on canine chromosome 26 in the region homologous with the DiGeorge critical region in humans (HSA22q11.2, which is causal for similar disorders). Linkage analysis highlighted "a region of 3.5 Mb at 32–35.5 Mb on CFA26". The causative mutation is still to be identified.
Have human generated variants been created, e.g. through genetic engineering and gene editing
German Pinscher (Dog) (VBO_0201454).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2011||Menzel, J., Distl, O. :|
|Unusual vascular ring anomaly associated with a persistent right aortic arch and an aberrant left subclavian artery in German pinschers. Vet J 187:352-5, 2011. Pubmed reference: 20106682. DOI: 10.1016/j.tvjl.2009.12.016.|
|Philipp, U., Menzel, J., Distl, O. :|
|A Rare Form of Persistent Right Aorta Arch in Linkage Disequilibrium with the DiGeorge Critical Region on CFA26 in German Pinschers. J Hered :S68-73, 2011. Pubmed reference: 21846749. DOI: 10.1093/jhered/esr053.|
- Created by Frank Nicholas on 28 May 2011
- Changed by Frank Nicholas on 07 Sep 2011
- Changed by Frank Nicholas on 22 May 2013