OMIA:001573-9615 : Leukaemia, chronic monocytic in Canis lupus familiaris (dog) |
Categories: Neoplasm , Haematopoietic system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 151410 (gene) , 608232 (trait) , 189980 (gene)
Mendelian trait/disorder: no
Mode of inheritance: Somatic mutation
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2011
Cross-species summary: Leukemia, chronic monocytic
Species-specific name: Chronic monocytic leukemia
Species-specific symbol: CMoL
Molecular basis: Cruz Cardona et al. (2011) reported the first identified case of an animal equivalent of "Philadelphia chromosome" - a chromosomal translocation that results in chronic leukemia. This translocation involves the gene known as breakpoint cluster region (BCR).
Associated genes:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| BCR | breakpoint cluster region | Canis lupus familiaris | 26 | NC_051830.1 (29260365..29385328) | BCR | Homologene, Ensembl , NCBI gene |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Canis lupus familiaris | 9 | NC_051813.1 (54162127..54019016) | ABL1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:001573-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Oh, J.H., Cho, J.Y. : |
| Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3. | |
| 2011 | Cruz Cardona, JA., Milner, R., Alleman, AR., Williams, C., Vernau, W., Breen, M., Tompkins, M. : |
| BCR-ABL translocation in a dog with chronic monocytic leukemia. Vet Clin Pathol 40:40-7, 2011. Pubmed reference: 21143615. DOI: 10.1111/j.1939-165X.2010.00277.x. |
Edit History
- Created by Frank Nicholas on 12 Jul 2011
- Changed by Frank Nicholas on 28 Sep 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Imke Tammen2 on 08 Dec 2020
- Changed by Imke Tammen2 on 10 Dec 2020