OMIA:001576-30521 : Coat colour, colour-sided in Bos grunniens (domestic yak) |
In other species: taurine cattle
Categories: Pigmentation phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 172800 (trait) , 164920 (gene)
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal
Disease-related: no
Key variant known: yes
Year key variant first reported: 2014
Molecular basis: Zhang et al. (2014) reported the same molecular basis of colour-sidedness in yaks as in cattle, namely (as reported by Durkin et al., 2012) "colour sidedness is determined by a first allele on chromosome 29 (Cs(29)), which results from the translocation of a 492-kilobase chromosome 6 segment encompassing KIT to chromosome 29, and a second allele on chromosome 6 (Cs(6)), derived from the first by repatriation of fused 575-kilobase chromosome 6 and 29 sequences to the KIT locus" [see OMIA 001576-9913] Medugorac et al. (2017) provided evidence that the colour-sided variant in yaks is due to introgression into yaks from Mongolian Turano cattle that have been herded with Mongolian yaks for more than 1,500 years, enabling the backcrossing of female yak-cattle hybrids to male yaks.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| KIT | Bos grunniens | - | no genomic information (-..-) | KIT | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001576-30521: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2017 | Medugorac, I., Graf, A., Grohs, C., Rothammer, S., Zagdsuren, Y., Gladyr, E., Zinovieva, N., Barbieri, J., Seichter, D., Russ, I., Eggen, A., Hellenthal, G., Brem, G., Blum, H., Krebs, S., Capitan, A. : |
| Whole-genome analysis of introgressive hybridization and characterization of the bovine legacy of Mongolian yaks. Nat Genet 49:470-475, 2017. Pubmed reference: 28135247. DOI: 10.1038/ng.3775. | |
| 2014 | Zhang, M.Q., Xu, X., Luo, S.J. : |
| The genetics of brown coat color and white spotting in domestic yaks (Bos grunniens). Anim Genet 45:652-9, 2014. Pubmed reference: 24989079. DOI: 10.1111/age.12191. | |
| 2012 | Durkin, K., Coppieters, W., Drögemüller, C., Ahariz, N., Cambisano, N., Druet, T., Fasquelle, C., Haile, A., Horin, P., Huang, L., Kamatani, Y., Karim, L., Lathrop, M., Moser, S., Oldenbroek, K., Rieder, S., Sartelet, A., Sölkner, J., Stålhammar, H., Zelenika, D., Zhang, Z., Leeb, T., Georges, M., Charlier, C. : |
| Serial translocation by means of circular intermediates underlies colour sidedness in cattle. Nature 482:81-4, 2012. Pubmed reference: 22297974. DOI: 10.1038/nature10757. |
Edit History
- Created by Frank Nicholas on 30 Apr 2015
- Changed by Frank Nicholas on 30 Apr 2015
- Changed by Frank Nicholas on 04 Oct 2017
- Changed by Imke Tammen2 on 17 Feb 2023