Categories: Homeostasis / metabolism phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: no

Considered a defect: yes

Key variant known: no

Cross-species summary: Oedema

Species-specific symbol: ed-1; ed-2

History: This disorder was first described by Savage et al. (1986).

Inheritance: From pedigree matings, Savage et al. 1982 (Oregon Agr. Exp. Sta. Tech. Paper No. 7851) postulated two autosomal loci, each with a recessive allele, which they named ed-1 and ed-2.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Savage et al. (1986): "embryonic malformation consisting of a fluid filled sac or sacs usually situated dorsally and caudally of both thighs of unhatched chicks ... . ... The edematous condition has been detected in embryos as early as 12 days of incubation and edema is still evident in those chicks alive at hatching."