OMIA:001761-9940 : Telomere length in Ovis aries (sheep)

In other species: dog , horse , pig , taurine cattle , goat

Categories: Normal phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 609113 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Froy et al. (2021) "dissected an observed positive association between TL [telomere length] and subsequent survival using multivariate quantitative genetic models. We found no evidence that telomere attrition was associated with increased mortality risk, suggesting that TL is not an important marker of biological aging or exposure to environmental stress in our study system. Instead, we find that among-individual differences in average TL are associated with increased lifespan. Our analyses suggest that this correlation between an individual's average TL and lifespan has a genetic basis. This demonstrates that TL has the potential to evolve under natural conditions, and suggests an important role of genetics underlying the widespread observation that short telomeres predict mortality."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Soay (Sheep) (VBO_0001605).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001761-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Zhang, N., Baker, E.C., Welsh, T.H., Riley, D.G. :
Telomere dynamics in livestock. Biology (Basel) 12:1389, 2023. Pubmed reference: 37997988. DOI: 10.3390/biology12111389.
2021 Froy, H., Underwood, S.L., Dorrens, J., Seeker, L.A., Watt, K., Wilbourn, R.V., Pilkington, J.G., Harrington, L., Pemberton, J.M., Nussey, D.H. :
Heritable variation in telomere length predicts mortality in Soay sheep. Proc Natl Acad Sci U S A 118, 2021. Pubmed reference: 33876756. DOI: 10.1073/pnas.2020563118.

Edit History

  • Created by Imke Tammen2 on 23 Apr 2021