OMIA:001777-9615 : Mammary tumour in Canis lupus familiaris (dog) |
In other species: chimpanzee , domestic cat , tiger
Categories: Neoplasm
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 114480 (trait)
Mendelian trait/disorder: unknown
Mode of inheritance: Somatic mutation
Disease-related: yes
Molecular basis: Arendt et al. (2023) investigate the somatic genetic aberrations occurring in canine mammary neoplasia by exome capture and next generation sequencing. Based on 55 tumor-normal pairs we identified the PIK3CA gene as the most commonly mutated gene in canine mammary tumors, with 25% of samples carrying mutations in this gene. A recurrent missense mutation was identified, p.H1047R, which is homologous to the human PIK3CA hotspot mutation found in different types of breast neoplasia. Mutations homologous to other known human mutation hotspots such as the PIK3CA p.E545K and the KRAS p.G12V/D were also identified. We identified copy number aberrations affecting important tumor suppressor and oncogenic pathways including deletions affecting the PTEN tumor suppressor gene.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Canis lupus familiaris | 34 | NC_051838.1 (12496918..12576076) | PIK3CA | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001777-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Çıldır, Ö.Ş., Özmen, Ö., Kul, S., Rişvanlı, A., Özalp, G., Sabuncu, A., Kul, O. : |
| Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients. Vet Med Sci 10:e1366, 2024. Pubmed reference: 38527110. DOI: 10.1002/vms3.1366. | |
| da Fonseca, I.I.M., Nagamine, M.K., Sato, A., Rossatto-Jr, C.A., Yeh, E.S., Dagli, M.L.Z. : | |
| Inhibitory effects of alpha-connexin carboxyl-terminal peptide on canine mammary epithelial cells: A study on benign and malignant phenotypes. Cancers (Basel) 16:820, 2024. Pubmed reference: 38398211. DOI: 10.3390/cancers16040820. | |
| Dolka, I., Czopowicz, M., Stopka, D., Wojtkowska, A., Kaszak, I., Sapierzyński, R. : | |
| Risk factor analysis and clinicopathological characteristics of female dogs with mammary tumours from a single-center retrospective study in Poland. Sci Rep 14:5569, 2024. Pubmed reference: 38448646. DOI: 10.1038/s41598-024-56194-z. | |
| Ferreira, T., Miranda, M., Pinto-Leite, R., Mano, J.F., Medeiros, R., Oliveira, P.A., Gama, A. : | |
| Integrated study of canine mammary tumors histopathology, immunohistochemistry, and cytogenetic findings. Vet Sci 11:409, 2024. Pubmed reference: 39330788. DOI: 10.3390/vetsci11090409. | |
| Ferreira, T., da Costa, R.M.G., Dias, F., Gama, A., Gaspar, V.M., Mano, J.F., Oliveira, P.A., Medeiros, R. : | |
| Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors. Geroscience 46:6641-6657, 2024. Pubmed reference: 38954129. DOI: 10.1007/s11357-024-01260-7. | |
| Gherman, L.M., Tomuleasa, D., Cismaru, A., Nutu, A., Berindan-Neagoe, I. : | |
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| Gutierrez-Riquelme, T., Karkossa, I., Schubert, K., Liebscher, G., Packeiser, E.M., Nolte, I., von Bergen, M., Murua Escobar, H., Aguilera-Rojas, M., Einspanier, R., Stein, T. : | |
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| Jeong, S.J., Oh, J.H., Cho, J.Y. : | |
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| Mei, C., Zhang, X., Zhi, Y., Liang, Z., Xu, H., Liu, Z., Liu, Y., Lyu, Y., Wang, H. : | |
| Isorhamnetin regulates programmed death ligand-1 expression by suppressing the EGFR-STAT3 signaling pathway in canine mammary tumors. Int J Mol Sci 25:670, 2024. Pubmed reference: 38203840. DOI: 10.3390/ijms25010670. | |
| Nosalova, N., Huniadi, M., Horňáková, Ľ., Valenčáková, A., Horňák, S., Nagoos, K., Vozar, J., Cizkova, D. : | |
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| Oliveira-Lopes, A.F., Götze, M.M., Lopes-Neto, B.E., Guerreiro, D.D., Bustamante-Filho, I.C., Moura, A.A. : | |
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| Razavirad, A., Rismanchi, S., Mortazavi, P., Muhammadnejad, A. : | |
| Canine mammary tumors as a potential model for human breast cancer in comparative oncology. Vet Med Int 2024:9319651, 2024. Pubmed reference: 38766503. DOI: 10.1155/2024/9319651. | |
| Rueda, J.R., Porto, C.D., Franco, R.P., da Costa, I.B., Bueno, L.M.C., Girio, R.J.S., Manhoso, F.F.R., Bueno, P.C.D.S., Repetti, C.S.F. : | |
| Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspects. Vet Med (Praha) 69:99-114, 2024. Pubmed reference: 38751991. DOI: 10.17221/4/2024-VETMED. | |
| Seung, B.J., Sur, J.H. : | |
| Detection of PIK3CA hotspot mutations in canine mammary tumors using droplet digital PCR: tissue validation and liquid biopsy feasibility. Sci Rep 14:25587, 2024. Pubmed reference: 39462049. DOI: 10.1038/s41598-024-76820-0. | |
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| PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia. Sci Rep 13:632, 2023. Pubmed reference: 36635367. DOI: 10.1038/s41598-023-27664-7. | |
| Canadas-Sousa, A., Santos, M., Dias-Pereira, P. : | |
| Protective effect of HER2 gene polymorphism rs24537331 in the outcome of canine mammary tumors. Animals (Basel) 13:1384, 2023. Pubmed reference: 37106947. DOI: 10.3390/ani13081384. | |
| Carvalho, P.T., Niza-Ribeiro, J., Amorim, I., Queiroga, F., Severo, M., Ribeiro, A.I., Pinello, K. : | |
| Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal. Front Vet Sci 10:1271097, 2023. Pubmed reference: 38098996. DOI: 10.3389/fvets.2023.1271097. | |
| Edmunds, G., Beck, S., Kale, K.U., Spasic, I., O'Neill, D., Brodbelt, D., Smalley, M.J. : | |
| Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. J Mammary Gland Biol Neoplasia 28:6, 2023. Pubmed reference: 36961631. DOI: 10.1007/s10911-023-09531-3. | |
| Ettlin, J., Bauer, A., Opitz, L., Malbon, A., Markkanen, E. : | |
| Deciphering stromal changes between metastatic and non-metastatic canine mammary carcinomas. J Mammary Gland Biol Neoplasia 28:14, 2023. Pubmed reference: 37391533. DOI: 10.1007/s10911-023-09542-0. | |
| Fedets, O.M., Dmytruk, K.V., Adaszek, L., Kurlyak, I.M., Dmytruk, O.V., Lisiecka, U., Winiarczyk, S. : | |
| Polymorphism of glutathione S-transferase P1 of dogs with mammary tumors. Vet Comp Oncol 21:270-278, 2023. Pubmed reference: 36808425. DOI: 10.1111/vco.12885. | |
| Ferreira, T., Gama, A., Seixas, F., Faustino-Rocha, A.I., Lopes, C., Gaspar, V.M., Mano, J.F., Medeiros, R., Oliveira, P.A. : | |
| Mammary glands of women, female dogs and female rats: Similarities and differences to be considered in breast cancer research. Vet Sci 10:379, 2023. Pubmed reference: 37368765. DOI: 10.3390/vetsci10060379. | |
| Gherman, L.M., Chiroi, P., Nuţu, A., Bica, C., Berindan-Neagoe, I. : | |
| Profiling canine mammary tumors: A potential model for studying human breast cancer. Vet J 303:S1090-0233(23)00106-5:106055, 2023. Pubmed reference: 38097103. DOI: 10.1016/j.tvjl.2023.106055. | |
| Kim, K., Song, J.E., Joo, J.B., Park, H.A., Choi, C.H., Je, C.Y., Kim, O.K., Park, S.W., Do, Y.J., Hur, T.Y., Park, S.I., Lee, C.M. : | |
| Genome-wide association study of mammary gland tumors in Maltese dogs. Front Vet Sci 10:1255981, 2023. Pubmed reference: 37859946. DOI: 10.3389/fvets.2023.1255981. | |
| Koo, H., Lee, S., Kim, W.H. : | |
| Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas. BMC Vet Res 19:231, 2023. Pubmed reference: 37932728. DOI: 10.1186/s12917-023-03761-7. | |
| Kwon, J.Y., Moskwa, N., Kang, W., Fan, T.M., Lee, C. : | |
| Canine as a comparative and translational model for human mammary tumor. J Breast Cancer 26:1-13, 2023. Pubmed reference: 36762784. DOI: 10.4048/jbc.2023.26.e4. | |
| Maqoud, F., Zizzo, N., Attimonelli, M., Tinelli, A., Passantino, G., Antonacci, M., Ranieri, G., Tricarico, D. : | |
| Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K<sup>+</sup> channel subunits in cancers: role in drug-disease interactions. Front Pharmacol 14:1115543, 2023. Pubmed reference: 37180726. DOI: 10.3389/fphar.2023.1115543. | |
| Mucha, A., Nowak, B., Dzimira, S., Liszka, B., Zatoń-Dobrowolska, M. : | |
| Identification of SNP markers for canine mammary gland tumours in females based on a genome-wide association study - preliminary results. J Vet Res 67:427-436, 2023. Pubmed reference: 37786854. DOI: 10.2478/jvetres-2023-0040. | |
| Oh, J.H., Cho, J.Y. : | |
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| Rodríguez-Bejarano, O.H., Roa, L., Vargas-Hernández, G., Botero-Espinosa, L., Parra-López, C., Patarroyo, M.A. : | |
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| Sammarco, A., Gomiero, C., Beffagna, G., Cavicchioli, L., Ferro, S., Michieletto, S., Orvieto, E., Patruno, M., Zappulli, V. : | |
| Epithelial-to-mesenchymal transition and phenotypic marker evaluation in human, canine, and feline mammary gland tumors. Animals (Basel) 13:878, 2023. Pubmed reference: 36899736. DOI: 10.3390/ani13050878. | |
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| Transcriptomic profile of canine mammary ductal carcinoma. Int J Mol Sci 24:5212, 2023. Pubmed reference: 36982287. DOI: 10.3390/ijms24065212. | |
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| Sirtuin 1 expression in canine mammary tumors: A pilot study. Animals (Basel) 13:2609, 2023. Pubmed reference: 37627400. DOI: 10.3390/ani13162609. | |
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| Tkaczyk-Wlizło, A., Kowal, K., Śmiech, A., Ślaska, B. : | |
| Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review. J Appl Genet 65:137-153, 2023. Pubmed reference: 38123735. DOI: 10.1007/s13353-023-00818-z. | |
| Varney, D., O'Neill, D., O'Neill, M., Church, D., Stell, A., Beck, S., Smalley, M.J., Brodbelt, D. : | |
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| Vazquez, E., Lipovka, Y., Cervantes-Arias, A., Garibay-Escobar, A., Haby, M.M., Queiroga, F.L., Velazquez, C. : | |
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| Yang, N.Y., Zheng, H.H., Yu, C., Ye, Y., Du, C.T., Xie, G.H. : | |
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| 2016 | Melin, M., Rivera, P., Arendt, M., Elvers, I., Murén, E., Gustafson, U., Starkey, M., Borge, K.S., Lingaas, F., Häggström, J., Saellström, S., Rönnberg, H., Lindblad-Toh, K. : |
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Edit History
- Created by Frank Nicholas on 17 Apr 2013
- Changed by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 16 Sep 2021
- Changed by Imke Tammen2 on 16 Jan 2023
- Changed by Imke Tammen2 on 23 Jan 2023
- Changed by Imke Tammen2 on 15 Feb 2023