OMIA:001777-9615 : Mammary tumour in Canis lupus familiaris (dog) |
In other species: chimpanzee , domestic cat
Categories: Neoplasm
Possibly relevant human trait(s) and/or gene(s) (MIM number): 114480 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Mode of inheritance: Somatic mutation
Considered a defect: yes
Molecular basis: Arendt et al. (2023) investigate the somatic genetic aberrations occurring in canine mammary neoplasia by exome capture and next generation sequencing. Based on 55 tumor-normal pairs we identified the PIK3CA gene as the most commonly mutated gene in canine mammary tumors, with 25% of samples carrying mutations in this gene. A recurrent missense mutation was identified, p.H1047R, which is homologous to the human PIK3CA hotspot mutation found in different types of breast neoplasia. Mutations homologous to other known human mutation hotspots such as the PIK3CA p.E545K and the KRAS p.G12V/D were also identified. We identified copy number aberrations affecting important tumor suppressor and oncogenic pathways including deletions affecting the PTEN tumor suppressor gene.
Genetic engineering:
Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Canis lupus familiaris | 34 | NC_051838.1 (12496918..12576076) | PIK3CA | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001777-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Araki, M., Noguchi, S., Kubo, Y., Yasuda, A., Koh, M., Otsuka, H., Yokosuka, M., Soeta, S. : |
| Expression of type VI collagen α3 chain in canine mammary carcinomas. Res Vet Sci 159:171-182, 2023. Pubmed reference: 37148736. DOI: 10.1016/j.rvsc.2023.04.010. | |
| Arendt, M.L., Sakthikumar, S., Melin, M., Elvers, I., Rivera, P., Larsen, M., Saellström, S., Lingaas, F., Rönnberg, H., Lindblad-Toh, K. : | |
| PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia. Sci Rep 13:632, 2023. Pubmed reference: 36635367. DOI: 10.1038/s41598-023-27664-7. | |
| Canadas-Sousa, A., Santos, M., Dias-Pereira, P. : | |
| Protective effect of HER2 gene polymorphism rs24537331 in the outcome of canine mammary tumors. Animals (Basel) 13, 2023. Pubmed reference: 37106947. DOI: 10.3390/ani13081384. | |
| Edmunds, G., Beck, S., Kale, K.U., Spasic, I., O'Neill, D., Brodbelt, D., Smalley, M.J. : | |
| Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. J Mammary Gland Biol Neoplasia 28:6, 2023. Pubmed reference: 36961631. DOI: 10.1007/s10911-023-09531-3. | |
| Ettlin, J., Bauer, A., Opitz, L., Malbon, A., Markkanen, E. : | |
| Deciphering stromal changes between metastatic and non-metastatic canine mammary carcinomas. J Mammary Gland Biol Neoplasia 28:14, 2023. Pubmed reference: 37391533. DOI: 10.1007/s10911-023-09542-0. | |
| Fedets, O.M., Dmytruk, K.V., Adaszek, L., Kurlyak, I.M., Dmytruk, O.V., Lisiecka, U., Winiarczyk, S. : | |
| Polymorphism of glutathione S-transferase P1 of dogs with mammary tumors. Vet Comp Oncol , 2023. Pubmed reference: 36808425. DOI: 10.1111/vco.12885. | |
| Ferreira, T., Gama, A., Seixas, F., Faustino-Rocha, A.I., Lopes, C., Gaspar, V.M., Mano, J.F., Medeiros, R., Oliveira, P.A. : | |
| Mammary glands of women, female dogs and female rats: Similarities and differences to be considered in breast cancer research. Vet Sci 10, 2023. Pubmed reference: 37368765. DOI: 10.3390/vetsci10060379. | |
| Kim, K., Song, J.E., Joo, J.B., Park, H.A., Choi, C.H., Je, C.Y., Kim, O.K., Park, S.W., Do, Y.J., Hur, T.Y., Park, S.I., Lee, C.M. : | |
| Genome-wide association study of mammary gland tumors in Maltese dogs. Front Vet Sci 10:1255981, 2023. Pubmed reference: 37859946. DOI: 10.3389/fvets.2023.1255981. | |
| Koo, H., Lee, S., Kim, W.H. : | |
| Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas. BMC Vet Res 19:231, 2023. Pubmed reference: 37932728. DOI: 10.1186/s12917-023-03761-7. | |
| Kwon, J.Y., Moskwa, N., Kang, W., Fan, T.M., Lee, C. : | |
| Canine as a comparative and translational model for human mammary tumor. J Breast Cancer , 2023. Pubmed reference: 36762784. DOI: 10.4048/jbc.2023.26.e4. | |
| Maqoud, F., Zizzo, N., Attimonelli, M., Tinelli, A., Passantino, G., Antonacci, M., Ranieri, G., Tricarico, D. : | |
| Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K<sup>+</sup> channel subunits in cancers: role in drug-disease interactions. Front Pharmacol 14:1115543, 2023. Pubmed reference: 37180726. DOI: 10.3389/fphar.2023.1115543. | |
| Mucha, A., Nowak, B., Dzimira, S., Liszka, B., Zatoń-Dobrowolska, M. : | |
| Identification of SNP markers for canine mammary gland tumours in females based on a genome-wide association study - preliminary results. J Vet Res 67:427-436, 2023. Pubmed reference: 37786854. DOI: 10.2478/jvetres-2023-0040. | |
| Oh, J.H., Cho, J.Y. : | |
| Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3. | |
| Sammarco, A., Gomiero, C., Beffagna, G., Cavicchioli, L., Ferro, S., Michieletto, S., Orvieto, E., Patruno, M., Zappulli, V. : | |
| Epithelial-to-mesenchymal transition and phenotypic marker evaluation in human, canine, and feline mammary gland tumors. Animals (Basel) 13, 2023. Pubmed reference: 36899736. DOI: 10.3390/ani13050878. | |
| Santos, D.B., Fernandez, G.J., Pardini, L.M.C., Pardini, M.I.M.C., Ferrasi, A.C. : | |
| Transcriptomic profile of canine mammary ductal carcinoma. Int J Mol Sci 24, 2023. Pubmed reference: 36982287. DOI: 10.3390/ijms24065212. | |
| Seitz, J., Bilsland, A., Puget, C., Baasner, I., Klopfleisch, R., Stein, T. : | |
| SFRP1 expression is inversely associated with metastasis formation in canine mammary tumours. J Mammary Gland Biol Neoplasia 28:15, 2023. Pubmed reference: 37402051. DOI: 10.1007/s10911-023-09543-z. | |
| Sgadari, M., Cacciola, N.A., Power, K., Martano, M., Restucci, B. : | |
| Sirtuin 1 expression in canine mammary tumors: A pilot study. Animals (Basel) 13, 2023. Pubmed reference: 37627400. DOI: 10.3390/ani13162609. | |
| Tamarindo, G.H., Novais, A.A., Chuffa, L.G.A., Zuccari, D.A.P.C. : | |
| Metabolic alterations in canine mammary tumors. Animals (Basel) 13, 2023. Pubmed reference: 37685021. DOI: 10.3390/ani13172757. | |
| Varney, D., O'Neill, D., O'Neill, M., Church, D., Stell, A., Beck, S., Smalley, M.J., Brodbelt, D. : | |
| Epidemiology of mammary tumours in bitches under veterinary care in the UK in 2016. Vet Rec :e3054, 2023. Pubmed reference: 37231594. DOI: 10.1002/vetr.3054. | |
| Vazquez, E., Lipovka, Y., Cervantes-Arias, A., Garibay-Escobar, A., Haby, M.M., Queiroga, F.L., Velazquez, C. : | |
| Canine mammary cancer: State of the art and future perspectives. Animals (Basel) 13, 2023. Pubmed reference: 37835752. DOI: 10.3390/ani13193147. | |
| Watson, J., Wang, T., Ho, K.L., Feng, Y., Dobbin, K.K., Zhao, S. : | |
| Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs. bioRxiv , 2023. Pubmed reference: 37034591. DOI: 10.1101/2023.03.02.530622. | |
| Yang, N.Y., Zheng, H.H., Yu, C., Ye, Y., Du, C.T., Xie, G.H. : | |
| Research progress of good markers for canine mammary carcinoma. Mol Biol Rep , 2023. Pubmed reference: 37943402. DOI: 10.1007/s11033-023-08863-x. | |
| Zhu, Z., Kitano, T., Morimatsu, M., Ochiai, K., Ishiguro-Oonuma, T., Oosumi, K., Lin, X., Orino, K., Yoshikawa, Y. : | |
| A highly conserved region in BRCA2 suppresses the RAD51-interaction activity of BRC repeats. Vet Sci 10, 2023. Pubmed reference: 36851449. DOI: 10.3390/vetsci10020145. | |
| 2021 | de Oliveira, J.R., Colombo, J., Gonçalves, F.M., de Carvalho, L.A.L., Costa, D.S., Henrique, T., Novais, A.A., Moschetta-Pinheiro, M.G., Chuffa, L.G.A., Coutinho, L.L., Santana, Á.E., Zuccari, D.A.P.C. : |
| Liquid biopsy can detect BRCA2 gene variants in female dogs with mammary neoplasia. Vet Comp Oncol , 2021. Pubmed reference: 34328705. DOI: 10.1111/vco.12758. | |
| 2020 | Kim, J.H. : |
| PIK3CA mutations matter for cancer in dogs. Res Vet Sci 133:39-41, 2020. Pubmed reference: 32932196. DOI: 10.1016/j.rvsc.2020.09.001. | |
| 2019 | Kowal, K., Ślaska, B., Bownik, A., Horecka, B., Gawor, J., Śmiech, A., Tkaczyk, A. : |
| Analysis of mitochondrial genome from Labrador (Canis lupus familiaris) with mammary gland tumour reveals novel mutations and polymorphisms. Ann. Anim. Sci. 19:619-632, 2019. DOI: 10.2478/aoas-2019-0027. | |
| Maués, T., El-Jaick, K.B., Costa, F.B., Freitas, P.V.S., Moreira, A.S., Castro, L., Ferreira, M.L.G., Ferreira, A.M.R. : | |
| Could polymorphisms in ABCB1 gene represent a genetic risk factor for the development of mammary tumors in dogs? Vet J 248:58-63, 2019. Pubmed reference: 31113564. DOI: 10.1016/j.tvjl.2019.04.010. | |
| 2018 | Canadas, A., Santos, M., Pinto, R., Medeiros, R., Dias-Pereira, P. : |
| Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours. Vet Comp Oncol , 2018. Pubmed reference: 30168237. DOI: 10.1111/vco.12438. | |
| 2016 | Melin, M., Rivera, P., Arendt, M., Elvers, I., Murén, E., Gustafson, U., Starkey, M., Borge, K.S., Lingaas, F., Häggström, J., Saellström, S., Rönnberg, H., Lindblad-Toh, K. : |
| Genome-wide analysis identifies germ-line risk factors associated with canine mammary tumours. PLoS Genet 12:e1006029, 2016. Pubmed reference: 27158822. DOI: 10.1371/journal.pgen.1006029. | |
| Surdyka, M., Slaska, B. : | |
| Defect of the mitochondrial DNA hypervariable region as a risk factor for canine mammary tumour. Vet Comp Oncol , 2016. Pubmed reference: 27198058. DOI: 10.1111/vco.12224. | |
| 2015 | Sun, W., Yang, X., Qiu, H., Zhang, D., Wang, H., Huang, J., Lin, D. : |
| Relationship between three novel SNPs of BRCA1 and canine mammary tumors. J Vet Med Sci 77:1541-3, 2015. Pubmed reference: 26156012. DOI: 10.1292/jvms.15-0044. | |
| 2013 | Borge, K.S., Melin, M., Rivera, P., Thoresen, S.I., Webster, M.T., von Euler, H., Lindblad-Toh, K., Lingaas, F. : |
| The ESR1 gene is associated with risk for canine mammary tumours. BMC Vet Res 9:69, 2013. Pubmed reference: 23574728. DOI: 10.1186/1746-6148-9-69. | |
| Dobson, J.M. : | |
| Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013. Pubmed reference: 23738139. DOI: 10.1155/2013/941275. | |
| 1998 | Schafer, K.A., Kelly, G., Schrader, R., Griffith, W.C., Muggenburg, B.A., Tierney, L.A., Lechner, J.E., Janovitz, E.B., Hahn, F.F. : |
| A canine model of familial mammary gland neoplasia Veterinary Pathology 35:168-177, 1998. Pubmed reference: 9598580. |
Edit History
- Created by Frank Nicholas on 17 Apr 2013
- Changed by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 16 Sep 2021
- Changed by Imke Tammen2 on 16 Jan 2023
- Changed by Imke Tammen2 on 23 Jan 2023
- Changed by Imke Tammen2 on 15 Feb 2023