OMIA:001777-9615 : Mammary tumour in Canis lupus familiaris (dog) |
In other species: chimpanzee , domestic cat , tiger , taurine cattle
Categories: Neoplasm
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 114480 (trait)
Single-gene trait/disorder: unknown
Mode of inheritance: Somatic mutation
Disease-related: yes
Molecular basis: Arendt et al. (2023) investigate the somatic genetic aberrations occurring in canine mammary neoplasia by exome capture and next generation sequencing. Based on 55 tumor-normal pairs we identified the PIK3CA gene as the most commonly mutated gene in canine mammary tumors, with 25% of samples carrying mutations in this gene. A recurrent missense mutation was identified, p.H1047R, which is homologous to the human PIK3CA hotspot mutation found in different types of breast neoplasia. Mutations homologous to other known human mutation hotspots such as the PIK3CA p.E545K and the KRAS p.G12V/D were also identified. We identified copy number aberrations affecting important tumor suppressor and oncogenic pathways including deletions affecting the PTEN tumor suppressor gene.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Canis lupus familiaris | 34 | NC_051838.1 (12496918..12576076) | PIK3CA | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001777-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Bhutta, Z.A., Choi, K.C. : |
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| Cassali, G.D., Nakagaki, K.Y.R., Salvi, M., Dos Reys, M.P., Rocha, M.A.N., de Campos, C.B., Ferreira, E., Rodrigues, A.C.B., Dos Reis, D.C., Damasceno, K.A., Estrela-Lima, A. : | |
| Canine, feline, and murine mammary tumors as a model for translational research in breast cancer. Vet Sci 12:189, 2025. Pubmed reference: 40005948. DOI: 10.3390/vetsci12020189. | |
| Hirano, S., Hifumi, T., Miyoshi, N. : | |
| Epidemiological analysis of mammary tumors in female dogs in Japan: A study based on Kyushu-Okinawa region. Vet J 310:S1090-0233(25)00005-X:106301, 2025. Pubmed reference: 39818359. DOI: 10.1016/j.tvjl.2025.106301. | |
| Hong, Y., Baik, H., Lee, J., Oh, W.S., Ryu, J., Baek, S.J. : | |
| A novel thrombospondin-1 variant as a potential diagnostic biomarker and therapeutic target in canine mammary tumor and osteosarcoma cells. J Vet Sci 26:e22, 2025. Pubmed reference: 40183909. DOI: 10.4142/jvs.24165. | |
| Inglebert, M., Dettwiler, M., He, C., Markkanen, E., Opitz, L., Naguleswaran, A., Rottenberg, S. : | |
| Individualized pooled CRISPR/Cas9 screenings identify CDK2 as a druggable vulnerability in a canine mammary carcinoma patient. Vet Sci 12:183, 2025. Pubmed reference: 40005944. DOI: 10.3390/vetsci12020183. | |
| Jeong, S.J., Lee, K.H., Cho, J.Y. : | |
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| Kato, Y., Kobayashi, N., Iwaide, S., Hisamoto, S., Koyama, S., Itoh, Y., Hisada, M., Machida, N., Nomura, K., Murakami, T. : | |
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| Xinyi, L., Jinlong, L., Bin, Z. : | |
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| 2024 | Çıldır, Ö.Ş., Özmen, Ö., Kul, S., Rişvanlı, A., Özalp, G., Sabuncu, A., Kul, O. : |
| Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients. Vet Med Sci 10:e1366, 2024. Pubmed reference: 38527110. DOI: 10.1002/vms3.1366. | |
| da Fonseca, I.I.M., Nagamine, M.K., Sato, A., Rossatto-Jr, C.A., Yeh, E.S., Dagli, M.L.Z. : | |
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| Deckwirth, V., Hundi, S., Hytönen, M.K., Hannula, S., Ellonen, P., Björkenheim, P., Sukura, A., Lohi, H. : | |
| Differential somatic coding variant landscapes between laser microdissected luminal epithelial cells from canine mammary invasive ductal solid carcinoma and comedocarcinoma. BMC Cancer 24:1524, 2024. Pubmed reference: 39696035. DOI: 10.1186/s12885-024-13239-w. | |
| Dolka, I., Czopowicz, M., Stopka, D., Wojtkowska, A., Kaszak, I., Sapierzyński, R. : | |
| Risk factor analysis and clinicopathological characteristics of female dogs with mammary tumours from a single-center retrospective study in Poland. Sci Rep 14:5569, 2024. Pubmed reference: 38448646. DOI: 10.1038/s41598-024-56194-z. | |
| Ferreira, T., Miranda, M., Pinto-Leite, R., Mano, J.F., Medeiros, R., Oliveira, P.A., Gama, A. : | |
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| Gherman, L.M., Tomuleasa, D., Cismaru, A., Nutu, A., Berindan-Neagoe, I. : | |
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| Proteomic analysis of extracellular vesicles derived from canine mammary tumour cell lines identifies protein signatures specific for disease state. BMC Vet Res 20:488, 2024. Pubmed reference: 39462388. DOI: 10.1186/s12917-024-04331-1. | |
| Jeong, S.J., Oh, J.H., Cho, J.Y. : | |
| ALYREF enhances breast cancer progression by regulating EZH2. Heliyon 10:e37749, 2024. Pubmed reference: 39386827. DOI: 10.1016/j.heliyon.2024.e37749. | |
| Ke, C.H., Lin, C.N., Lin, C.S. : | |
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| Mei, C., Liu, Y., Liu, Z., Zhi, Y., Jiang, Z., Lyu, X., Wang, H. : | |
| Dysregulated signaling pathways in canine mammary tumor and human triple negative breast cancer: Advances and potential therapeutic targets. Int J Mol Sci 26:145, 2024. Pubmed reference: 39796003. DOI: 10.3390/ijms26010145. | |
| Mei, C., Zhang, X., Zhi, Y., Liang, Z., Xu, H., Liu, Z., Liu, Y., Lyu, Y., Wang, H. : | |
| Isorhamnetin regulates programmed death ligand-1 expression by suppressing the EGFR-STAT3 signaling pathway in canine mammary tumors. Int J Mol Sci 25:670, 2024. Pubmed reference: 38203840. DOI: 10.3390/ijms25010670. | |
| Nosalova, N., Huniadi, M., Horňáková, Ľ., Valenčáková, A., Horňák, S., Nagoos, K., Vozar, J., Cizkova, D. : | |
| Canine mammary tumors: Classification, biomarkers, traditional and personalized therapies. Int J Mol Sci 25:2891, 2024. Pubmed reference: 38474142. DOI: 10.3390/ijms25052891. | |
| Oliveira-Lopes, A.F., Götze, M.M., Lopes-Neto, B.E., Guerreiro, D.D., Bustamante-Filho, I.C., Moura, A.A. : | |
| Molecular and pathobiology of canine mammary tumour: Defining a translational model for human breast cancer. Vet Comp Oncol 22:340-358, 2024. Pubmed reference: 39011576. DOI: 10.1111/vco.12996. | |
| Razavirad, A., Rismanchi, S., Mortazavi, P., Muhammadnejad, A. : | |
| Canine mammary tumors as a potential model for human breast cancer in comparative oncology. Vet Med Int 2024:9319651, 2024. Pubmed reference: 38766503. DOI: 10.1155/2024/9319651. | |
| Rueda, J.R., Porto, C.D., Franco, R.P., da Costa, I.B., Bueno, L.M.C., Girio, R.J.S., Manhoso, F.F.R., Bueno, P.C.D.S., Repetti, C.S.F. : | |
| Mammary neoplasms in female dogs: Clinical, diagnostic and therapeutic aspects. Vet Med (Praha) 69:99-114, 2024. Pubmed reference: 38751991. DOI: 10.17221/4/2024-VETMED. | |
| Seung, B.J., Sur, J.H. : | |
| Detection of PIK3CA hotspot mutations in canine mammary tumors using droplet digital PCR: tissue validation and liquid biopsy feasibility. Sci Rep 14:25587, 2024. Pubmed reference: 39462049. DOI: 10.1038/s41598-024-76820-0. | |
| Tkaczyk-Wlizło, A., Kowal, K., Śmiech, A., Ślaska, B. : | |
| Occurrence of mammary gland tumours in male dogs and its weak association with development of testicular tumours: a review. J Appl Genet 65:137-153, 2024. Pubmed reference: 38123735. DOI: 10.1007/s13353-023-00818-z. | |
| 2023 | Araki, M., Noguchi, S., Kubo, Y., Yasuda, A., Koh, M., Otsuka, H., Yokosuka, M., Soeta, S. : |
| Expression of type VI collagen α3 chain in canine mammary carcinomas. Res Vet Sci 159:171-182, 2023. Pubmed reference: 37148736. DOI: 10.1016/j.rvsc.2023.04.010. | |
| Arendt, M.L., Sakthikumar, S., Melin, M., Elvers, I., Rivera, P., Larsen, M., Saellström, S., Lingaas, F., Rönnberg, H., Lindblad-Toh, K. : | |
| PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia. Sci Rep 13:632, 2023. Pubmed reference: 36635367. DOI: 10.1038/s41598-023-27664-7. | |
| Canadas-Sousa, A., Santos, M., Dias-Pereira, P. : | |
| Protective effect of HER2 gene polymorphism rs24537331 in the outcome of canine mammary tumors. Animals (Basel) 13:1384, 2023. Pubmed reference: 37106947. DOI: 10.3390/ani13081384. | |
| Carvalho, P.T., Niza-Ribeiro, J., Amorim, I., Queiroga, F., Severo, M., Ribeiro, A.I., Pinello, K. : | |
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| Associations between dog breed and clinical features of mammary epithelial neoplasia in bitches: an epidemiological study of submissions to a single diagnostic pathology centre between 2008-2021. J Mammary Gland Biol Neoplasia 28:6, 2023. Pubmed reference: 36961631. DOI: 10.1007/s10911-023-09531-3. | |
| Ettlin, J., Bauer, A., Opitz, L., Malbon, A., Markkanen, E. : | |
| Deciphering stromal changes between metastatic and non-metastatic canine mammary carcinomas. J Mammary Gland Biol Neoplasia 28:14, 2023. Pubmed reference: 37391533. DOI: 10.1007/s10911-023-09542-0. | |
| Fedets, O.M., Dmytruk, K.V., Adaszek, L., Kurlyak, I.M., Dmytruk, O.V., Lisiecka, U., Winiarczyk, S. : | |
| Polymorphism of glutathione S-transferase P1 of dogs with mammary tumors. Vet Comp Oncol 21:270-278, 2023. Pubmed reference: 36808425. DOI: 10.1111/vco.12885. | |
| Ferreira, T., Gama, A., Seixas, F., Faustino-Rocha, A.I., Lopes, C., Gaspar, V.M., Mano, J.F., Medeiros, R., Oliveira, P.A. : | |
| Mammary glands of women, female dogs and female rats: Similarities and differences to be considered in breast cancer research. Vet Sci 10:379, 2023. Pubmed reference: 37368765. DOI: 10.3390/vetsci10060379. | |
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| Relationship between three novel SNPs of BRCA1 and canine mammary tumors. J Vet Med Sci 77:1541-3, 2015. Pubmed reference: 26156012. DOI: 10.1292/jvms.15-0044. | |
| 2013 | Borge, K.S., Melin, M., Rivera, P., Thoresen, S.I., Webster, M.T., von Euler, H., Lindblad-Toh, K., Lingaas, F. : |
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Edit History
- Created by Frank Nicholas on 17 Apr 2013
- Changed by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 16 Sep 2021
- Changed by Imke Tammen2 on 16 Jan 2023
- Changed by Imke Tammen2 on 23 Jan 2023
- Changed by Imke Tammen2 on 15 Feb 2023