OMIA 001801-9940 : Fecundity, High fertility, FecG(H) in Ovis aries

Possibly relevant human trait(s) and/or gene(s) (MIM number): 601918

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2004

Species-specific symbol: FecG(H)

Breeds: Belclare, Irish Cambridge.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GDF9 growth differentiation factor 9 Ovis aries 5 NC_040256.1 (46547527..46544800) GDF9 Homologene, Ensembl, NCBI gene


By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Belclare Irish Cambridge Fecundity, High fertility, FecG GDF9 FecG(H) missense Oar_rambouillet_v1.0 5 g.46545225G>A c.1184C>T p.(S395F) Oar_v3.1 position is g.41841212G>A; protein and cDNA position based on NP_001136360.2 and NM_001142888.2 respectively 2004 14627550 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool. The genomic location on Oar_rambouillet_v1.0 was determined by Katie Eager, EMAI, NSW Department of Primary Industries.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2013 Juengel, J.L., Davis, G.H., McNatty, K.P. :
Using sheep lines with mutations in single genes to better understand ovarian function. Reproduction 146:R111-23, 2013. Pubmed reference: 23801782. DOI: 10.1530/REP-12-0509.
Mullen, M.P., Hanrahan, J.P., Howard, D.J., Powell, R. :
Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep. PLoS One 8:e53172, 2013. Pubmed reference: 23301039. DOI: 10.1371/journal.pone.0053172.
Shabir, M., Ganai, T.A., Misra, S.S., Shah, R., Ahmad, T. :
Polymorphism study of growth differentiation factor 9B (GDF9B) gene and its association with reproductive traits in sheep. Gene 515:432-8, 2013. Pubmed reference: 23266806. DOI: 10.1016/j.gene.2012.12.018.
2011 Javanmard, A., Azadzadeh, N., Esmailizadeh, A.K. :
Mutations in bone morphogenetic protein 15 and growth differentiation factor 9 genes are associated with increased litter size in fat-tailed sheep breeds. Vet Res Commun 35:157-67, 2011. Pubmed reference: 21327517. DOI: 10.1007/s11259-011-9467-9.
Roy, J., Polley, S., De, S., Mukherjee, A., Batabyal, S., Pan, S., Brahma, B., Datta, T.K., Goswami, S.L. :
Polymorphism of fecundity genes (FecB, FecX, and FecG) in the Indian Bonpala sheep. Anim Biotechnol 22:151-62, 2011. Pubmed reference: 21774623. DOI: 10.1080/10495398.2011.589239.
2010 Polley, S., De, S., Brahma, B., Mukherjee, A., Vinesh, P.V., Batabyal, S., Arora, J.S., Pan, S., Samanta, A.K., Datta, T.K., Goswami, S.L. :
Polymorphism of BMPR1B, BMP15 and GDF9 fecundity genes in prolific Garole sheep. Trop Anim Health Prod 42:985-93, 2010. Pubmed reference: 20020203. DOI: 10.1007/s11250-009-9518-1.
2004 Hanrahan, JP., Gregan, SM., Mulsant, P., Mullen, M., Davis, GH., Powell, R., Galloway, SM. :
Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod 70:900-9, 2004. Pubmed reference: 14627550. DOI: 10.1095/biolreprod.103.023093.

Edit History

  • Created by Frank Nicholas on 04 May 2013