OMIA:001818-9615 : Factor XIII deficiency, F13A1-related in Canis lupus familiaris (dog) |
In other species: taurine cattle
Categories: Haematopoietic system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 613225 (trait) , 134570 (gene)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Mode of inheritance: Probably autosomal recessive
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2026
Species-specific name: FXIII
Molecular basis: Pieples et al. (2026) identified a homozygous variant (c.1234_1239delinsTCAA) in exon 11 of F13A1 (omia.variant:1910) that predicts a frameshift and premature stop codon as likely causal variant in a Black and Tan Coonhound.
Clinical features: Pieples et al. (2026): "A 4-month-old male Black and Tan Coonhound presented with spontaneous hemoperitoneum, thrombocytopenia, and persistent bleeding after surgical procedures. .... A functional FXIII deficiency was identified ... ."
Breeds:
Black and Tan Coonhound (Dog) (VBO_0200168),
Mixed Breed (Dog) (VBO_0200902).
Breeds in which the phene or likely causal variants have been documented. If a likely causal variant has been documented, see variant-specific breed information in the variant table. (Breed information may be incomplete).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| F13A1 | coagulation factor XIII A chain | Canis lupus familiaris | 35 | NC_051839.1 (6430557..6267724) | F13A1 | Ensembl, NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Variant Type | Variant Effect | Source of Genetic Variant | AVCG Pathogenicity Classification* | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1910 | Black and Tan Coonhound (Dog) | Factor XIII deficiency | F13A1 | delins, small (<=20) | frameshift | Naturally occurring variant | Not currently evaluated | UU_Cfam_GSD_1.0 | 35 | NC_049256.1:g.7525276_7525281delinsTTGA | XM_038584097.1:c.1234_1239delinsTCAA | XP_038440025.1:p.(G412Sfs*7) | 2026 | 42184124 |
* Variant pathogenicity for single-gene diseases as evaluated according to the Animal Variant Classification Guidelines (AVCG) by the Variant Pathogenicity Working Group of the International Society of Animal Genetics (ISAG) Animal Genetic Testing Standardization (AGTS) Standing Committee: P = pathogenic, LP = likely pathogenic, VUS = variant of unknown significance, LB = likely benign, B = benign. For more information (including details on the classification of each variant) see LINKS.
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:001818-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2026 | Pieples, L.A., Cook, S.R., Tinsman, A., Brooks, M.B., Goggs, R., Evans, J.M. : |
| Identification of an F13A1 frameshift variant associated with factor XIII deficiency in a Coonhound dog with severe coagulopathy. J Vet Intern Med 40:aalag093, 2026. Pubmed reference: 42184124. DOI: 10.1093/jvimsj/aalag093. | |
| 2014 | Kong, L.R., Snead, E.C., Burgess, H., Dhumeaux, M.P. : |
| Recurrent episodes of severe bleeding caused by congenital factor XIII deficiency in a dog. J Am Vet Med Assoc 245:1147-52, 2014. Pubmed reference: 25356716. DOI: 10.2460/javma.245.10.1147. |
Edit History
- Created by Imke Tammen on 03 Jul 2026
- Changed by Imke Tammen on 03 Jul 2026