OMIA:001821-9940 : Coat colour, albinism, oculocutaneous type IV in Ovis aries (sheep) |
In other species: Japanese medaka , western gorilla , dog , taurine cattle
Categories: Pigmentation phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606574 (trait) , 227240 (trait) , 606202 (gene)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Mode of inheritance: Probably autosomal recessive
Disease-related: no
Key variant known: yes
Year key variant first reported: 2024
Species-specific name: Suffolk white-fleece phenotype
Molecular basis: Tearle et al. (2025): "The Suffolk white-fleece phenotype is associated with a novel 3-bp deletion in the gene SLC45A2 ... . The deletion results in the removal of one amino acid from the protein." (omia.variant:1761)
Breed:
Suffolk (Sheep) (VBO_0001627).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| SLC45A2 | solute carrier family 45 member 2 | Ovis aries | 16 | NC_056069.1 (39944924..39979329) | SLC45A2 | Homologene, Ensembl , NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1761 | Suffolk (Sheep) | Suffolk white fleece | SLC45A2 | deletion, small (<=20) | Naturally occurring variant | ARS-UI_Ramb_v3.0 | 16 | NC_056069.1:g39966131_39966133del | XM_004017064.5:c.661_663del | XP_004017113.5:p.(F221del) | 2025 | 39608806 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:001821-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Tearle, R.G., Chen, T., Brien, F.D. : |
| A 3-bp deletion in the SLC45A2 gene is associated with loss of fleece pigmentation in black-fleeced Suffolk sheep. Anim Genet 56:e13495, 2025. Pubmed reference: 39608806. DOI: 10.1111/age.13495. | |
| 1993 | Rowett, M.A., Fleet, M.R. : |
| Albinism in a Suffolk sheep. J Hered 84:67-9, 1993. Pubmed reference: 8440890. DOI: 10.1093/oxfordjournals.jhered.a111279. |
Edit History
- Created by Imke Tammen2 on 27 Dec 2024
- Changed by Imke Tammen2 on 28 Dec 2024