OMIA 001891-9615 : Ectopic ureter in Canis lupus familiaris

In other species: horse

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Inheritance: From records of 1611 Entlebucher Mountain Dogs, Fritsche et al. (2013) estimated heritability of this disorder to be 65%, with some evidence of involvement of a gene of large effect.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2018 Gallana, M., Utsunomiya, Y.T., Dolf, G., Pintor Torrecilha, R.B., Falbo, A.K., Jagannathan, V., Leeb, T., Reichler, I., Sölkner, J., Schelling, C. :
Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs. Anim Genet :, 2018. Pubmed reference: 30276844. DOI: 10.1111/age.12728.
2014 Fritsche, R., Dolf, G., Schelling, C., Hungerbuehler, S.O., Hagen, R., Reichler, I.M. :
Inheritance of ectopic ureters in Entlebucher Mountain Dogs. J Anim Breed Genet 131:146-52, 2014. Pubmed reference: 24628724. DOI: 10.1111/jbg.12055.
Newman, M., Landon, B. :
Surgical treatment of a duplicated and ectopic ureter in a dog. J Small Anim Pract 55:475-8, 2014. Pubmed reference: 25168741. DOI: 10.1111/jsap.12227.
2013 Fritsche, R., Dolf, G., Schelling, C., Hungerbuehler, S.O., Hagen, R., Reichler, I.M. :
Inheritance of ectopic ureters in Entlebucher Mountain Dogs. Journal of Animal Breeding and Genetics :, 2013. DOI: 10.1111/jbg.12055.
Novellas, R., Stone, J., Pratschke, K., Hammond, G. :
Duplicated ectopic ureter in a nine-year-old Labrador. J Small Anim Pract 54:386-9, 2013. Pubmed reference: 23551207. DOI: 10.1111/jsap.12056.
2012 Reichler, I.M., Eckrich Specker, C., Hubler, M., Boos, A., Haessig, M., Arnold, S. :
Ectopic ureters in dogs: clinical features, surgical techniques and outcome. Vet Surg 41:515-22, 2012. Pubmed reference: 22486391. DOI: 10.1111/j.1532-950X.2012.00952.x.
2011 Bitterli, F. :
Prävalenz und klinische Relevanz ektopischer Ureteren beim Entlebucher und Appenzeller Sennenhund. Dissertation, Vetsuisse Faculty, University of Zurich, Zurich :, 2011.
2010 North, C., Kruger, J.M., Venta, P.J., Miller, J.M., Rosenstein, D.S., Randall, E.K., White, B., Fitzgerald, S.D. :
Congenital ureteral ectopia in continent and incontinent-related Entlebucher mountain dogs: 13 cases (2006-2009). J Vet Intern Med 24:1055-62, 2010. Pubmed reference: 20666980. DOI: 10.1111/j.1939-1676.2010.0562.x.
Smith, A.L., Radlinsky, M.G., Rawlings, C.A. :
Cystoscopic diagnosis and treatment of ectopic ureters in female dogs: 16 cases (2005-2008). J Am Vet Med Assoc 237:191-5, 2010. Pubmed reference: 20632793. DOI: 10.2460/javma.237.2.191.
Thomas, P.C., Yool, D.A. :
Delayed-onset urinary incontinence in five female dogs with ectopic ureters. J Small Anim Pract 51:224-6, 2010. Pubmed reference: 20214729. DOI: 10.1111/j.1748-5827.2009.00893.x.
Yoon, H.Y., Mann, F.A., Punke, J.P., Jeong, S.W. :
Bilateral ureteral ectopia with renal dysplasia and urolithiasis in a dog. J Am Anim Hosp Assoc 46:209-14, 2010. Pubmed reference: 20439946.
2006 Eckrich Specker, C. :
Ektopische Ureteren beim Hund: Eine retrospektive Analyse von 30 Fällen. Dissertation, Vetsuisse Faculty, University of Zurich, Zurich :, 2006.
2004 Samii, V.F., McLoughlin, M.A., Mattoon, J.S., Drost, W.T., Chew, D.J., DiBartola, S.P., Hoshaw-Woodard, S. :
Digital fluoroscopic excretory urography, digital fluoroscopic urethrography, helical computed tomography, and cystoscopy in 24 dogs with suspected ureteral ectopia. J Vet Intern Med 18:271-81, 2004. Pubmed reference: 15188811.
2003 Cannizzo, K.L., McLoughlin, M.A., Mattoon, J.S., Samii, V.F., Chew, D.J., DiBartola, S.P. :
Evaluation of transurethral cystoscopy and excretory urography for diagnosis of ectopic ureters in female dogs: 25 cases (1992-2000). J Am Vet Med Assoc 223:475-81, 2003. Pubmed reference: 12930085.
Oglesby, P.A., Carter, A. :
Ultrasonographic diagnosis of unilateral ectopic ureter in a Labrador dog. J S Afr Vet Assoc 74:84-6, 2003. Pubmed reference: 15029953.
Taney, K.G., Moore, K.W., Carro, T., Spencer, C. :
Bilateral ectopic ureters in a male dog with unilateral renal agenesis. J Am Vet Med Assoc 223:817-20, 810, 2003. Pubmed reference: 14507098.
2002 Lautzenhiser, S.J., Bjorling, D.E. :
Urinary incontinence in a dog with an ectopic ureterocele. J Am Anim Hosp Assoc 38:29-32, 2002. Pubmed reference: 11804312.
2000 Holt, P.E., Thrusfield, M.V., Hotston Moore, A. :
Breed predisposition to ureteral ectopia in bitches in the UK. Veterinary Record 146:561 only, 2000.
Koie, H., Yamaya, Y., Sakai, T. :
Four cases of lowered urethral pressure in canine ectopic ureter. J Vet Med Sci 62:1221-2, 2000. Pubmed reference: 11129871.
1999 Anderson, C.C., Cook, C.R., Pope, E.R. :
What is your diagnosis? Ectopic ureter. J Am Vet Med Assoc 214:1321-2, 1999. Pubmed reference: 10319171.
1998 Lamb, C.R., Gregory, S.P. :
Ultrasonographic findings in 14 dogs with ectopic ureter. Vet Radiol Ultrasound 39:218-23, 1998. Pubmed reference: 9634190.
1995 Holt, P.E., Moore, A.H. :
Canine ureteral ectopia: an analysis of 175 cases and comparison of surgical treatments. Veterinary Record 136:345 only, 1995.
1988 Dean, P.W., Bojrab, M.J., Constantinescu, G.M. :
Canine ectopic ureter. Compend. Contin. Educ. Vet. 10:146-162, 1988.
1986 Hager, D.A., Blevins, W.E. :
Ectopic ureter in a dog: extension from the kidney to the urinary bladder and to the urethra. J Am Vet Med Assoc 189:309-10, 1986. Pubmed reference: 3744991.
1984 Hayes, H.M. :
Breed associations of canine ectopic ureter: a study of 217 female cases. J. Small Anim. Pract. 25:501–504, 1984.
1982 Holt, P.E., Gibbs, C., Pearson, H. :
Canine ectopic ureter – a review of twenty-nine cases. J. Small Anim. Pract. 23:195–208, 1982.
1981 Smith, C.W., Stowater, J.L., Kneller, S.K. :
Ectopic ureter in the dog: a review of cases. J. Am. Anim. Hosp. Assoc. 17:245-248, 1981.
1980 Smith, C.W., Stowater, J.L., Kneller, S.K. :
Bilateral ectopic ureter in a male dog with urinary incontinence. J Am Vet Med Assoc 177:1022-4, 1980. Pubmed reference: 7462081.
1977 Johnston, G.R., Osbourne, C.A., Wilson, J.W., Yano, B.L. :
Familial ureteral ectopia in the dog. J. Am. Anim. Hosp. Assoc. 13:168–170, 1977.
1976 Holt, P.E. :
Ectopic ureter in the bitch. Vet Rec 98:299-300, 1976. Pubmed reference: 1274140.
1975 Osborne, C.A., Dieterich, H.F., Hanlon, G.F., Anderson, L.D. :
Urinary incontinence due to ectopic ureter in a male dog. J Am Vet Med Assoc 166:911-4, 1975. Pubmed reference: 1168184.
1974 Hayes, H.M. :
Ectopic ureter in dogs: epidemiologic features. Teratology 10:129-32, 1974. Pubmed reference: 4428421. DOI: 10.1002/tera.1420100206.
1973 Lane, J.G. :
Canine ectopic ureter--two further case reports. J Small Anim Pract 14:555-60, 1973. Pubmed reference: 4789312.
1971 Seidenberg, L., Knecht, C.D. :
Ectopic ureter in the dog. J Am Vet Med Assoc 159:876-7, 1971. Pubmed reference: 5106547.
1969 Osborne, C.A., Perman, V. :
Ectopic ureter in a male dog. J Am Vet Med Assoc 154:273-8, 1969. Pubmed reference: 5812515.

Edit History

  • Created by Frank Nicholas on 25 Nov 2013
  • Changed by Frank Nicholas on 25 Nov 2013