OMIA:001896-9796 : Exercise-induced pulmonary haemorrhage in Equus caballus (horse) |
Categories: Haematopoietic system phene
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: yes
Key variant known: no
Species-specific name: Also known as exercise-induced epistaxis syndrome, or even just epistaxis, but the latter is inadequate because it does not capture the exercise-induced nature of this disorder.
Species-specific symbol: EIPH
Breed:
Thoroughbred (Horse) (VBO_0001083).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:001896-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Hansen, S., Otten, N.D., Nissen, S.D., Carstensen, H., Hopster-Iversen, C., Fjeldborg, J., Staun, S.H., Fenner, M., Hesselkilde, E.M., Buhl, R. : |
| Atrial fibrillation as a risk factor for exercise-induced pulmonary haemorrhage following a standardised exercise test. Equine Vet J 56:552-561, 2024. Pubmed reference: 37654233. DOI: 10.1111/evj.13995. | |
| Leite, R.O., Albertino, L.G., Sperandio, L.M.S., Campos, F., Campos, R., Borges, A.S., Oliveira-Filho, J.P. : | |
| Evaluation of variants in the ENTPD1 and ENTPD2 genes in athletic horses with exercise-induced pulmonary haemorrhage. BMC Vet Res 20:346, 2024. Pubmed reference: 39103835. DOI: 10.1186/s12917-024-04192-8. | |
| Shawaf, T. : | |
| Jugular venous thrombosis as a risk factor for exercise-induced pulmonary hemorrhage in thoroughbred racehorses. Open Vet J 14:1111-1116, 2024. Pubmed reference: 38938431. DOI: 10.5455/OVJ.2024.v14.i5.4. | |
| 2023 | Burns, J.J., MacMillan, K.M., John, E. : |
| Prevalence of exercise-induced pulmonary hemorrhage, tracheal mucus and recurrent laryngeal neuropathy in competitive draft pulling horses. J Equine Vet Sci 129:104895, 2023. Pubmed reference: 37517672. DOI: 10.1016/j.jevs.2023.104895. | |
| Mahalingam-Dhingra, A., Bedenice, D., Mazan, M.R. : | |
| Bronchoalveolar lavage hemosiderosis in lightly active or sedentary horses. J Vet Intern Med 37:1243-1249, 2023. Pubmed reference: 36975043. DOI: 10.1111/jvim.16692. | |
| 2021 | Dahlgren, A.R., Tablin, F., Finno, C.J. : |
| Genetics of equine bleeding disorders. Equine Vet J 53:30-37, 2021. Pubmed reference: 32463964. DOI: 10.1111/evj.13290. | |
| 2019 | Blott, S., Cunningham, H., Malkowski, L., Brown, A., Rauch, C. : |
| A mechanogenetic model of exercise-induced pulmonary haemorrhage in the thoroughbred horse. Genes (Basel) 10:880, 2019. Pubmed reference: 31683933. DOI: 10.3390/genes10110880. | |
| Bonomo, C.C.M., Michelotto, P.V., Viccino, C., Barussi, F.C.M., Fernandes, W.R. : | |
| Occurrence of exercise-induced pulmonary haemorrhage in show jumping horses. Vet J 248:91-94, 2019. Pubmed reference: 31113571. DOI: 10.1016/j.tvjl.2019.05.003. | |
| Crispe, E.J., Secombe, C.J., Perera, D.I., Manderson, A.A., Turlach, B.A., Lester, G.D. : | |
| Exercise-induced pulmonary haemorrhage in Thoroughbred racehorses: a longitudinal study. Equine Vet J 51:45-51, 2019. Pubmed reference: 29675969. DOI: 10.1111/evj.12957. | |
| 2017 | Crispe, E.J., Lester, G.D., Secombe, C.J., Perera, D.I. : |
| The association between exercise-induced pulmonary haemorrhage and race-day performance in Thoroughbred racehorses. Equine Vet J 49:584-589, 2017. Pubmed reference: 28118491. DOI: 10.1111/evj.12671. | |
| 2016 | Poole, D.C., Erickson, H.H. : |
| Exercise-induced pulmonary hemorrhage: where are we now? Vet Med (Auckl) 7:133-148, 2016. Pubmed reference: 30050846. DOI: 10.2147/VMRR.S120421. | |
| 2015 | Boudreaux, M.K., Koehler, J., Habecker, P.L., Del Piero, F. : |
| Evaluation of the genes encoding CD39/NTPDase-1 and CD39L1/NTPDase-2 in horses with and without abnormal hemorrhage and in horses with pathologic evidence of exercise-induced pulmonary hemorrhage. Vet Clin Pathol 44:617-25, 2015. Pubmed reference: 26642303. DOI: 10.1111/vcp.12303. | |
| Gerber, V., Tessier, C., Marti, E. : | |
| Genetics of upper and lower airway diseases in the horse. Equine Vet J 47:390-7, 2015. Pubmed reference: 24773614. DOI: 10.1111/evj.12289. | |
| Hinchcliff, K.W., Couetil, L.L., Knight, P.K., Morley, P.S., Robinson, N.E., Sweeney, C.R., van Erck, E. : | |
| Exercise induced pulmonary hemorrhage in horses: American College of Veterinary Internal Medicine consensus statement. J Vet Intern Med 29:743-58, 2015. Pubmed reference: 25996660. DOI: 10.1111/jvim.12593. | |
| Morley, P.S., Hinchcliff, K.W. : | |
| Letter to the Editor regarding article on exercise-induced pulmonary haemorrhage at the Hong Kong Jockey Club. Equine Vet J 47:372-3, 2015. Pubmed reference: 25598392. DOI: 10.1111/evj.12379. | |
| Morley, P.S., Bromberek, J.L., Saulez, M.N., Hinchcliff, K.W., Guthrie, A.J. : | |
| Exercise-induced pulmonary haemorrhage impairs racing performance in Thoroughbred racehorses. Equine Vet J 47:358-65, 2015. Pubmed reference: 25290262. DOI: 10.1111/evj.12368. | |
| Preston, S., Riggs, C.M. : | |
| Descriptive analysis of longitudinal endoscopy for exercise-induced pulmonary haemorrhage in Thoroughbred racehorses training and racing at the Hong Kong Jockey Club - letter. Equine Vet J 47:374-5, 2015. Pubmed reference: 25597337. DOI: 10.1111/evj.12388. | |
| Reardon, R.J., Boden, L.A., Mellor, D.J., Love, S., Newton, R.J., Stirk, A.J., Parkin, T.D. : | |
| Risk factors for epistaxis in jump racing in Great Britain (2001-2009). Vet J 205:44-9, 2015. Pubmed reference: 26045356. DOI: 10.1016/j.tvjl.2015.04.003. | |
| Richards, A.D. : | |
| Letter to the editor. Equine Vet J 47:376, 2015. Pubmed reference: 25597229. DOI: 10.1111/evj.12380. | |
| Riggs, C.M., Preston, S. : | |
| Response to Richards letter. Equine Vet J 47:377, 2015. Pubmed reference: 25894302. DOI: 10.1111/evj.12405. | |
| Sullivan, S., Hinchcliff, K. : | |
| Update on exercise-induced pulmonary hemorrhage. Vet Clin North Am Equine Pract 31:187-98, 2015. Pubmed reference: 25770069. DOI: 10.1016/j.cveq.2014.11.011. | |
| Sullivan, S.L., Whittem, T., Morley, P.S., Hinchcliff, K.W. : | |
| A systematic review and meta-analysis of the efficacy of furosemide for exercise-induced pulmonary haemorrhage in Thoroughbred and Standardbred racehorses. Equine Vet J 47:341-9, 2015. Pubmed reference: 25291214. DOI: 10.1111/evj.12373. | |
| Sullivan, S.L., Anderson, G.A., Morley, P.S., Hinchcliff, K.W. : | |
| Prospective study of the association between exercise-induced pulmonary haemorrhage and long-term performance in Thoroughbred racehorses. Equine Vet J 47:350-7, 2015. Pubmed reference: 24617564. DOI: 10.1111/evj.12263. | |
| 2014 | Velie, B.D., Raadsma, H.W., Wade, C.M., Knight, P.K., Hamilton, N.A. : |
| Heritability of epistaxis in the Australian Thoroughbred racehorse population. Vet J 202:274-8, 2014. Pubmed reference: 25011713. DOI: 10.1016/j.tvjl.2014.06.010. | |
| 2013 | Langford, J.L., Thomson, P.C., Knight, P.K. : |
| Epistaxis in racehorses: risk factors and effects on career. Aust Vet J 91:198-203, 2013. Pubmed reference: 23614515. DOI: 10.1111/avj.12049. | |
| 2011 | Derksen, F., Williams, K., Stack, A. : |
| Exercise-induced pulmonary hemorrhage in horses: the role of pulmonary veins. Compend Contin Educ Vet 33:E6, 2011. Pubmed reference: 21870340. | |
| Michelotto, P.V., Muehlmann, L.A., Zanatta, A.L., Bieberbach, E.W., Kryczyk, M., Fernandes, L.C., Nishiyama, A. : | |
| Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. Vet J 190:e3-6, 2011. Pubmed reference: 22108190. DOI: 10.1016/j.tvjl.2010.08.009. | |
| 2010 | Hinchcliff, K.W., Morley, P.S., Jackson, M.A., Brown, J.A., Dredge, A.F., O'Callaghan, P.A., McCaffrey, J.P., Slocombe, R.F., Clarke, A.F. : |
| Risk factors for exercise-induced pulmonary haemorrhage in Thoroughbred racehorses. Equine Vet J Suppl :228-34, 2010. Pubmed reference: 21059011. DOI: 10.1111/j.2042-3306.2010.00245.x. | |
| 2008 | Williams, KJ., Derksen, FJ., de Feijter-Rupp, H., Pannirselvam, RR., Steel, CM., Robinson, NE. : |
| Regional pulmonary veno-occlusion: a newly identified lesion of equine exercise-induced pulmonary hemorrhage. Vet Pathol 45:316-26, 2008. Pubmed reference: 18487488. DOI: 10.1354/vp.45-3-316. | |
| 2005 | Araya, O., Palma, P., Salvi, M., Bustamante, H., Vits, L. : |
| Endoscopic determination of exercise-induced pulmonary haemorrhage in Chilean Criollo horses. Vet J 169:311-3, 2005. Pubmed reference: 15727928. DOI: 10.1016/j.tvjl.2004.02.002. | |
| Hinchcliff, KW., Jackson, MA., Morley, PS., Brown, JA., Dredge, AE., O'Callaghan, PA., McCaffrey, JP., Slocombe, RE., Clarke, AE. : | |
| Association between exercise-induced pulmonary hemorrhage and performance in Thoroughbred racehorses. J Am Vet Med Assoc 227:768-74, 2005. Pubmed reference: 16178399. | |
| Hinchcliff, KW., Jackson, MA., Brown, JA., Dredge, AF., O'Callaghan, PA., McCaffrey, JP., Morley, PS., Slocombe, RE., Clarke, AF. : | |
| Tracheobronchoscopic assessment of exercise-induced pulmonary hemorrhage in horses. Am J Vet Res 66:596-8, 2005. Pubmed reference: 15900938. | |
| Newton, JR., Rogers, K., Marlin, DJ., Wood, JL., Williams, RB. : | |
| Risk factors for epistaxis on British racecourses: evidence for locomotory impact-induced trauma contributing to the aetiology of exercise-induced pulmonary haemorrhage. Equine Vet J 37:402-11, 2005. Pubmed reference: 16163941. | |
| 2004 | Weideman, H., Schoeman, SJ., Jordaan, GF. : |
| The inheritance of liability to epistaxis in the southern African Thoroughbred. J S Afr Vet Assoc 75:158-62, 2004. Pubmed reference: 15830598. | |
| 2002 | Doucet, M.Y., Viel, L. : |
| Clinical, radiographic, endoscopic, bronchoalveolar lavage and lung biopsy findings in horses with exercise-induced pulmonary hemorrhage Canadian Veterinary Journal - Revue Veterinaire Canadienne 43:195-202, 2002. | |
| 2001 | Anon. : |
| Frequency of and risk factors for epistaxis associated with exercise induced pulmonary hemorrhage in horses: 251,609 race starts (1992-1997) (vol 218, pg 1462, 2001) Journal of the American Veterinary Medical Association 218:1965, 2001. | |
| Erickson, H.H., Hildreth, T.S., Poole, D.C., Cox, J.H. : | |
| Management of exercise-induced pulmonary hemorrhage in nonracing performance horses Compendium on Continuing Education for the Practicing Veterinarian 23:1090-1093, 2001. | |
| Takahashi, T., Hiraga, A., Ohmura, H., Kai, M., Jones, J.H. : | |
| Frequency of and risk factors for epistaxis associated with exercise-induced pulmonary hemorrhage in horses: 251,609 race starts (1992-1997) Journal of the American Veterinary Medical Association 218:1462-1464, 2001. Pubmed reference: 11345311. | |
| 2000 | Erickson, H.H., Kindig, C.A., Poole, D.C. : |
| Exercise-induced pulmonary hemorrhage: A new concept for prevention Journal of Equine Veterinary Science 20:164-167, 2000. | |
| 1999 | Hinchcliff, K.W. : |
| Effects of furosemide on athletic performance and exercise-induced pulmonary hemorrhage in horses Journal of the American Veterinary Medical Association 215:630-635, 1999. Pubmed reference: 10476706. | |
| 1998 | Meyer, T.S., Fedde, M.R., Gaughan, E.M., Langsetmo, I., Erickson, H.H. : |
| Quantification of exercise-induced pulmonary haemorrhage with bronchoalveolar lavage Equine Veterinary Journal 30:284-288, 1998. Pubmed reference: 9705109. | |
| Robertshaw, D. : | |
| Regional distribution of exercise-induced pulmonary haemorrhage - horses and antelopes Equine Veterinary Journal 30:181-182, 1998. Pubmed reference: 9622316. | |
| Schroter, R.C., Marlin, D.J., Denny, E. : | |
| Exercise-induced pulmonary haemorrhage (EIPH) in horses results from locomotory impact induced trauma - a novel, unifying concept Equine Veterinary Journal 30:186-192, 1998. Pubmed reference: 9622318. | |
| Weiss, D.J., Smith, C.M. : | |
| Haemorrheological alterations associated with competitive racing activity in horses - implications for exercise-induced pulmonary haemorrhage (eiph) [Review] Equine Veterinary Journal 30:7-12, 1998. Pubmed reference: 9458393. | |
| 1997 | Derksen, F.J. : |
| Oxidant injury and nitric oxide - a role in exercise-induced pulmonary haemorrhage Veterinary Journal 153:119-121, 1997. | |
| Harkins, J.D., Mundy, G.D., Stanley, S.D., Harrison, L., Poonacha, K.B., Williams, N.A., Tobin, T. : | |
| Exercise-induced pulmonary hemorrhage - a review of the etiology and pathogenesis [Review] Equine Practice 19:22-28, 1997. | |
| Landolsi, F., Chabchoub, A., Harti, Y., Ghorbel, A. : | |
| Electrocardiographic parameters on horses suffering from exercise induced epistaxis syndrome [French] Revue de Medecine Veterinaire 148:969-974, 1997. | |
| 1995 | Erickson, H.H., Odea, J.C., Pascoe, J., Robinson, N.E., Sweeney, C.R. : |
| Exercise-induced pulmonary hemorrhage (eiph) Journal of Equine Veterinary Science 15:464-466, 1995. | |
| Harkins, J.D., Tobin, T. : | |
| Racing horses, nitroglycerin and exercise induced pulmonary haemorrhage (EIPH) Equine Veterinary Journal 27:240-241, 1995. Pubmed reference: 8536657. | |
| Hilsenroth, R. : | |
| Exercise-induced pulmonary hemorrhage (EIPH) Equine Practice 17:7, 1995. | |
| 1994 | Aguileratejero, E., Pascoe, J.R., Smith, B.L., Tyler, W.S., Woliner, M.J. : |
| Evaluation of a technique for detection of pulmonary hemorrhage in horses, using carbon monoxide uptake American Journal of Veterinary Research 55:1032-1036, 1994. Pubmed reference: 7978621. | |
| Anon. : | |
| Conference on Bleeders Journal of Equine Veterinary Science 14:77, 1994. | |
| Art, T., Lekeux, P. : | |
| Exercise-Induced Pulmonary Hemorrhage in Horses Annales de Medecine Veterinaire 138:145-153, 1994. | |
| Erickson, H. : | |
| Exercise-Induced Pulmonary Hemorrhage (EIPH) Journal of Equine Veterinary Science 14:438, 1994. | |
| Fio, L. : | |
| How Lasix Works to Stop Bleeding in Racehorses Journal of Equine Veterinary Science 14:381-382, 1994. | |
| Geor, R.J., Weiss, D.J., Smith, C.M. : | |
| Hemorheologic alterations induced by incremental treadmill exercise in Thoroughbreds American Journal of Veterinary Research 55:854-861, 1994. Pubmed reference: 7944028. | |
| Jones, W.E. : | |
| Poor Performance and Upper Airway Dysfunction Journal of Equine Veterinary Science 14:107-108, 1994. | |
| Lapointe, J.M., Vrins, A., Mccarvill, E. : | |
| A Survey of Exercise-Induced Pulmonary Haemorrhage in Quebec Standardbred Racehorses Equine Veterinary Journal 26:482-485, 1994. Pubmed reference: 7889923. | |
| Manohar, M., Hutchens, E., Coney, E. : | |
| Frusemide Attenuates the Exercise-Induced Rise in Pulmonary Capillary Blood Pressure in Horses Equine Veterinary Journal 26:51-54, 1994. Pubmed reference: 8143666. | |
| Manohar, M. : | |
| Pulmonary Vascular Pressures of Thoroughbreds Increase Rapidly and to a Higher Level with Rapid Onset of High- Intensity Exercise Than Slow Onset Equine Veterinary Journal 26:496-499, 1994. Pubmed reference: 7889926. | |
| Weiss, D.J., Geor, R.J., Smith, C.M. : | |
| Effects of Echinocytosis on Hermorrheologic Values and Exercise Performance in Horses American Journal of Veterinary Research 55:204-210, 1994. Pubmed reference: 8172408. | |
| West, J.B., Mathieucostello, O. : | |
| Stress Failure of Pulmonary Capillaries as a Mechanism for Exercise Induced Pulmonary Haemorrhage in the Horse Equine Veterinary Journal 26:441-447, 1994. Pubmed reference: 7889916. | |
| 1993 | Fedde, M.R., Wood, S.C. : |
| Rheological Characteristics of Horse Blood - Significance During Exercise Respiration Physiology 94:323-335, 1993. Pubmed reference: 8108610. | |
| Mckane, S.A., Canfield, P.J., Rose, R.J. : | |
| Equine Bronchoalveolar Lavage Cytology - Survey of Thoroughbred Racehorses in Training Australian Veterinary Journal 70:401-404, 1993. Pubmed reference: 8280021. | |
| 1992 | Cook, W.R. : |
| Questions Theory on Cause of Exercise-Induced Pulmonary Hemorrhage Journal of the American Veterinary Medical Association 201:1661-1662, 1992. Pubmed reference: 1293093. | |
| Derksen, F.J., Slocombe, R.F., Gray, P.R., Robinson, N.E. : | |
| Exercise-Induced Pulmonary Hemorrhage in Horses with Experimentally Induced Allergic Lung Disease American Journal of Veterinary Research 53:15-21, 1992. Pubmed reference: 1371655. | |
| Dhupa, N., Littman, M.P. : | |
| Epistaxis Compendium on Continuing Education for the Practicing Veterinarian 14:1033-1042, 1992. | |
| Hagedorn, H.W., Bock, M., Schulz, R. : | |
| Acetylsalicylic Acid and Blood Coagulation in the Horse Deutsche Tierarztliche Wochenschrift 99:410-412, 1992. Pubmed reference: 1425318. | |
| Mahony, C., Rantanen, N.W., Demichael, J.A., Kincaid, B. : | |
| Spontaneous Echocardiographic Contrast in the Thoroughbred - High Prevalence in Racehorses and a Characteristic Abnormality in Bleeders Equine Veterinary Journal 24:129-133, 1992. Pubmed reference: 1582391. | |
| Mcclay, C.B., Weiss, D.J., Smith, C.M., Gordon, B. : | |
| Evaluation of Hemorheologic Variables as Implications for Exercise-Induced Pulmonary Hemorrhage in Racing Thoroughbreds American Journal of Veterinary Research 53:1380-1385, 1992. Pubmed reference: 1510314. | |
| Roberts, L.J., Knight, V.A. : | |
| A Physiologic Concept of Exercise-Induced Pulmonary Hemorrhage in Horses Journal of the American Veterinary Medical Association 201:666-667, 1992. Pubmed reference: 1399759. | |
| Schumacher, J., Dean, P., Welch, B. : | |
| Epistaxis in 2 Horses with Dacryohemorrhea Journal of the American Veterinary Medical Association 200:366-367, 1992. Pubmed reference: 1548174. | |
| Smith, J.D., Arthur, R., Barton, J., Bowen, E., Byars, D., Derksen, F., Erickson, H., Gowen, B., Hinchcliff, K., Manohar, M., Ocallaghan, M., Pascoe, J., Robinson, E., Sams, R., Soma, L., Sweeney, C., Tobin, T. : | |
| A Workshop - Exercise-Induced Pulmonary Hemorrhage Findings .2 Equine Practice 14:9, 1992. | |
| Smith, J.D., Arthur, R., Barton, J., Bowen, E., Byars, D., Derksen, F., Erickson, H., Gowen, B., Hinchcliff, K., Manohar, M., Ocallaghan, M., Pascoe, J., Robinson, E., Sams, R., Soma, L., Sweeney, C., Tobin, T. : | |
| Exercise-Induced Pulmonary Hemorrhage Findings .3 Equine Practice 14:28-31, 1992. | |
| 1991 | Pascoe, J.R. : |
| Exercise-Induced Pulmonary Hemorrhage Equine Respiratory Disorders :237-252, 1991. | |
| Sweeney, C.R. : | |
| Exercise-Induced Pulmonary Hemorrhage Veterinary Clinics of North America-Equine Practice 7:93-104, 1991. | |
| 1990 | Arthur, R.M. : |
| Respiratory Problems in the Racehorse Veterinary Clinics of North America-Equine Practice 6:179-196, 1990. | |
| Macnamara, B., Bauer, S., Iafe, J. : | |
| Endoscopic Evaluation of Exercise Induced Pulmonary Hemorrhage and Chronic Obstructive Pulmonary Disease in Association with Poor Performance in Racing Standardbreds Journal of the American Veterinary Medical Association 196:443-445, 1990. Pubmed reference: 2298674. | |
| Mcdowell, M., Wickler, S.J. : | |
| Effect of Naproxen on Bleeding Time in the Horse Journal of Equine Veterinary Science 10:162-163, 1990. | |
| Mckeever, K.H., Hinchcliff, K.W., Kociba, G.J., Reed, S.M., Muir, W.W. : | |
| Changes in Coagulation and Fibrinolysis in Horses During Exercise American Journal of Veterinary Research 51:1335-1339, 1990. Pubmed reference: 2396779. | |
| 1989 | Ocallaghan, M.W. : |
| Bleeding from the Nose :107-121, 1989. | |
| 1980 | Arthur, R.M. : |
| The clinical management of exercise-induced pulmonary hemorrhage at Southern California throughbred racetracks Proceedings of the Annual Convention of the American Association of Equine Practitioners 26:441-444, 1980. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Carrie Finno on 11 Dec 2013
- Changed by Frank Nicholas on 19 Mar 2020
- Changed by Imke Tammen2 on 28 Aug 2021
- Changed by Imke Tammen2 on 27 Oct 2022