OMIA 001907-9913 : Haplotype with homozygous deficiency 05-1351 and 05-1476 in Bos taurus
Mendelian trait/disorder: yes Mode of inheritance: Autosomal Recessive Lethal Considered a defect: yes Key variant known: no Mapping: By genotyping each of 7,937 Nordic Holstein bulls with the BovineSNP50 BeadChip, yielding 36,387 informative autosomal SNPs, and then searching for 25-marker haplotypes that never occur as a homozygote where the minimum expectation is 6 occurrences, Sahana et al. (2013) "identified 17 homozygote deficient haplotypes which could be loosely clustered into eight genomic regions harboring possible recessive lethal alleles". One of these eight regions is marked by haplotypes 05-1351 and 05-1476 located between 106.7–114.4 Mb on chromosome BTA5. Breed: Nordic Holstein.
|2013||Sahana, G., Nielsen, U.S., Aamand, G.P., Lund, M.S., Guldbrandtsen, B. :|
|Novel harmful recessive haplotypes identified for fertility traits in nordic holstein cattle. PLoS One 8:e82909, 2013. Pubmed reference: 24376603. DOI: 10.1371/journal.pone.0082909.|
- Created by Frank Nicholas on 12 Feb 2014
- Changed by Frank Nicholas on 12 Feb 2014