Categories: Nervous system phene

Possible human homologues (MIM numbers): 608236 (trait) , 608136 (gene)

Cross-species summary: An inherited polyneuropathy observed in Leonberger and Saint Bernard dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT) disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed polyneuropathy, characterized by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as inspiratory stridor and dyspnea.

Species in which this phene is found:
dog (Canis lupus familiaris)