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OMIA:001942-9913 : Haplotype with homozygous deficiency JH2 in Bos taurus (taurine cattle)

Categories: Mortality / aging (incl. embryonic lethal)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive lethal

Considered a defect: yes

Key variant known: no

Species-specific name: Haplotype JH2

Species-specific symbol: JH2

Mapping: Using a strategy similar to that of VanRaden et al. (2011), VanRaden et al. (2014) discovered reduced-fertility haplotype JH2, located on chromosome BTA26 at 8.8-9.4Mb.

In their table of reduced-fertility haplotypes, Cole et al. (2014) list this haplotype as being located at 8,812,759 – 9,414,082bp on chromosome BTA26.

Breed: Jersey (Cattle) (VBO_0000250).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2015). OMIA:001942-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2016 Cole, J.B., Null, D.J., VanRaden, P.M. :
Phenotypic and genetic effects of recessive haplotypes on yield, longevity, and fertility. J Dairy Sci 99:7274-88, 2016. Pubmed reference: 27394947 . DOI: 10.3168/jds.2015-10777.
2014 Cole, J.B., VanRaden, P.M., Null, D.J., Hutchison, J.L., Cooper, T.A., Hubbard, S.M. :
Haplotype tests for recessive disorders that affect fertility and other traits. AIP RESEARCH REPORT GENOMIC3 (09-13); http://aipl.arsusda.gov/reference/recessive_haplotypes_ARR-G3.html :, 2014.
VanRaden, P.M., Null, D., Hutchison, J., Bickhart, D., Cooper, T. :
Jersey haplotyoe 2 (JH2). Changes to evaluation system (August 2014). Council on Dairy Cattle Breeding. https://www.cdcb.us/reference/changes/eval1408.htm :, 2014.
2011 VanRaden, P.M., Olson, K.M., Null, D.J., Hutchison, J.L. :
Harmful recessive effects on fertility detected by absence of homozygous haplotypes. J Dairy Sci 94:6153-61, 2011. Pubmed reference: 22118103 . DOI: 10.3168/jds.2011-4624.

Edit History


  • Created by Frank Nicholas on 31 Oct 2014
  • Changed by Frank Nicholas on 31 Oct 2014
  • Changed by Frank Nicholas on 24 Mar 2015