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OMIA:001963-9913 : Schwannomatosis in Bos taurus (taurine cattle)

Categories: Neoplasm

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 162091 (trait) , 615670 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Also known as peripheral nerve sheath tumors (PNST)

Mapping: In a GWAS conducted on 28 affected and 28 normal Danish Holsteins, each genotyped with the BovineSNP50 BeadChip, yielding 40,962 informative SNPs, Grossi et al. (2015) identified a candidate region in the vicinity of 20.9Mb (UMD3) on chromosome BTA27.

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Holstein (black and white) (Cattle) (VBO_0000237).
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2021). OMIA:001963-9913: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2021 Jacinto, J.G., Bolcato, M., Sheahan, B.J., Muscatello, L.V., Gentile, A., Avallone, G., Benazzi, C. :
Congenital tumours and tumour-like lesions in calves: a review. J Comp Pathol 184:84-94, 2021. Pubmed reference: 33894884. DOI: 10.1016/j.jcpa.2021.02.003.
2014 Grossi, A.B., Agerholm, J.S., Christensen, K., Jensen, H.E., Leifsson, P.S., Bendixen, C., Karlskov-Mortensen, P., Fredholm, M. :
A hereditary disposition for bovine peripheral nerve sheath tumors in Danish Holstein cattle. Acta Vet Scand 56:85, 2014. Pubmed reference: 25492402. DOI: 10.1186/s13028-014-0085-8.

Edit History


  • Created by Frank Nicholas on 17 May 2015
  • Changed by Frank Nicholas on 17 May 2015
  • Changed by Imke Tammen2 on 17 Aug 2021