OMIA 001989-9615 : Onychomadesis, symmetrical in Canis lupus familiaris

Possibly relevant human trait(s) and/or gene(s) (MIM number): 107000 (trait)

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Key variant known: no

Species-specific name: Symmetrical onychomadesis or symmetrical lupoid onychodystrophy (SLO)

Mapping: A GWAS conducted by Dahlgren et al. (2012) "in 225 Gordon Setters identified a single region associated with symmetrical onychomadesis on chromosome 12 (spanning about 3.3 mb)."

A GWAS in Border Collies by Gershony et al. (2019) highlighted two regions on CFA12 and one region on CFA17.

Gershony et al. (2021) "Case-control association was employed on whole genome sequencing data to uncover putative causative variants in SLO within the CFA12 and CFA17 associated regions. ... Although no SLO-associated protein-coding variants were identified on CFA17, multiple variants, many with predicted damaging effects, were identified within potential candidate genes on CFA12. Furthermore, many potentially damaging alleles were fully correlated with the presence of DLA class II risk haplotypes for SLO, suggesting that the variants may reflect DLA class II haplotype association with disease or vice versa. ... all were predictive of risk for SLO and, with judicious assessment, their application in selective breeding may prove useful to reduce the incidence of SLO in the breed."

Breeds: Border Collie, Gordon Setter.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M. :
Whole genome sequencing reveals multiple linked genetic variants on canine chromosome 12 associated with risk for symmetrical lupoid onychodystrophy (SLO) in the Bearded Collie. Genes (Basel) 12:1265, 2021. Pubmed reference: 34440439. DOI: 10.3390/genes12081265.
2019 Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M., Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M. :
Novel locus associated with symmetrical lupoid onychodystrophy in the Bearded Collie. Genes (Basel) 10:635, 2019. Pubmed reference: 31443497. DOI: 10.3390/genes10090635.
2016 Dahlgren, S., Ziener, M.L., Lingaas, F. :
A genome-wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs. Anim Genet 47:708-716, 2016. Pubmed reference: 27629549. DOI: 10.1111/age.12469.
2015 Ziener, M.L., Dahlgren, S., Thoresen, S.I., Lingaas, F. :
Genetics and epidemiology of hypothyroidism and symmetrical onychomadesis in the Gordon setter and the English setter. Canine Genet Epidemiol 2:12, 2015. Pubmed reference: 26401340. DOI: 10.1186/s40575-015-0025-6.
2010 Wilbe, M., Ziener, M.L., Aronsson, A., Harlos, C., Sundberg, K., Norberg, E., Andersson, L., Lindblad-Toh, K., Hedhammar, A., Andersson, G., Lingaas, F. :
DLA class II alleles are associated with risk for canine symmetrical lupoid onychodystropy (SLO) PLoS ONE 5:e12332, 2010. Pubmed reference: 20808798. DOI: 10.1371/journal.pone.0012332.
2008 Ziener, ML., Bettenay, SV., Mueller, RS. :
Symmetrical onychomadesis in Norwegian Gordon and English setters. Vet Dermatol 19:88-94, 2008. Pubmed reference: 18336425. DOI: 10.1111/j.1365-3164.2008.00650.x.
2006 Barrand, KR. :
What is your diagnosis? Symmetrical lupoid onychodystrophy. J Small Anim Pract 47:757-9, 2006. Pubmed reference: 17201832. DOI: 10.1111/j.1748-5827.2006.00118.x.
2001 Auxilia, ST., Hill, PB., Thoday, KL. :
Canine symmetrical lupoid onychodystrophy: a retrospective study with particular reference to management. J Small Anim Pract 42:82-7, 2001. Pubmed reference: 11263704.
Bohnhorst, J.O., Hanssen, I., Moen, T. :
Antinuclear antibodies (ANA) in Gordon setters with symmetrical lupoid onychodystrophy and black hair follicular dysplasia Acta Veterinaria Scandinavica 42:323-329, 2001. Pubmed reference: 11887392.
2000 Verde, M.T., Basurco, A. :
Symmetrical lupoid onychodystrophy in a crossbred pointer dog: long-term observations Veterinary Record 146:376-378, 2000. Pubmed reference: 10803984.
1995 Scott, D.W., Rousselle, S., Miller, W.H. :
Symmetrical lupoid onychodystrophy in dogs: A retrospective analysis of 18 cases (1989-1993) Journal of the American Animal Hospital Association 31:194-201, 1995. Pubmed reference: 7634051.

Edit History


  • Created by Frank Nicholas on 11 Apr 2016
  • Changed by Frank Nicholas on 18 Oct 2016
  • Changed by Frank Nicholas on 20 Sep 2019
  • Changed by Imke Tammen2 on 12 Feb 2022