OMIA:001989-9615 : Onychomadesis, symmetrical in Canis lupus familiaris (dog)
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 107000 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: no
Mode of inheritance: Multifactorial
Considered a defect: yes
Key variant known: no
Species-specific name: Symmetrical onychomadesis or symmetrical lupoid onychodystrophy (SLO)
Mapping: A GWAS conducted by Dahlgren et al. (2012) "in 225 Gordon Setters identified a single region associated with symmetrical onychomadesis on chromosome 12 (spanning about 3.3 mb)."
A GWAS in Border Collies by Gershony et al. (2019) highlighted two regions on CFA12 and one region on CFA17.
Gershony et al. (2021) "Case-control association was employed on whole genome sequencing data to uncover putative causative variants in SLO within the CFA12 and CFA17 associated regions. ... Although no SLO-associated protein-coding variants were identified on CFA17, multiple variants, many with predicted damaging effects, were identified within potential candidate genes on CFA12. Furthermore, many potentially damaging alleles were fully correlated with the presence of DLA class II risk haplotypes for SLO, suggesting that the variants may reflect DLA class II haplotype association with disease or vice versa. ... all were predictive of risk for SLO and, with judicious assessment, their application in selective breeding may prove useful to reduce the incidence of SLO in the breed."
Breeds in which the phene has been documented. For breeds in which a likely causal variant has been documented, see the variant table below
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M. :|
|Whole genome sequencing reveals multiple linked genetic variants on canine chromosome 12 associated with risk for symmetrical lupoid onychodystrophy (SLO) in the Bearded Collie. Genes (Basel) 12:1265, 2021. Pubmed reference: 34440439 . DOI: 10.3390/genes12081265.|
|2019||Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M., Gershony, L.C., Belanger, J.M., Hytönen, M.K., Lohi, H., Oberbauer, A.M. :|
|Novel locus associated with symmetrical lupoid onychodystrophy in the Bearded Collie. Genes (Basel) 10:635, 2019. Pubmed reference: 31443497 . DOI: 10.3390/genes10090635.|
|2016||Dahlgren, S., Ziener, M.L., Lingaas, F. :|
|A genome-wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs. Anim Genet 47:708-716, 2016. Pubmed reference: 27629549 . DOI: 10.1111/age.12469.|
|2015||Ziener, M.L., Dahlgren, S., Thoresen, S.I., Lingaas, F. :|
|Genetics and epidemiology of hypothyroidism and symmetrical onychomadesis in the Gordon setter and the English setter. Canine Genet Epidemiol 2:12, 2015. Pubmed reference: 26401340 . DOI: 10.1186/s40575-015-0025-6.|
|2010||Wilbe, M., Ziener, M.L., Aronsson, A., Harlos, C., Sundberg, K., Norberg, E., Andersson, L., Lindblad-Toh, K., Hedhammar, A., Andersson, G., Lingaas, F. :|
|DLA class II alleles are associated with risk for canine symmetrical lupoid onychodystropy (SLO) PLoS ONE 5:e12332, 2010. Pubmed reference: 20808798 . DOI: 10.1371/journal.pone.0012332.|
|2008||Ziener, ML., Bettenay, SV., Mueller, RS. :|
|Symmetrical onychomadesis in Norwegian Gordon and English setters. Vet Dermatol 19:88-94, 2008. Pubmed reference: 18336425 . DOI: 10.1111/j.1365-3164.2008.00650.x.|
|2006||Barrand, KR. :|
|What is your diagnosis? Symmetrical lupoid onychodystrophy. J Small Anim Pract 47:757-9, 2006. Pubmed reference: 17201832 . DOI: 10.1111/j.1748-5827.2006.00118.x.|
|2001||Auxilia, ST., Hill, PB., Thoday, KL. :|
|Canine symmetrical lupoid onychodystrophy: a retrospective study with particular reference to management. J Small Anim Pract 42:82-7, 2001. Pubmed reference: 11263704 .|
|Bohnhorst, J.O., Hanssen, I., Moen, T. :|
|Antinuclear antibodies (ANA) in Gordon setters with symmetrical lupoid onychodystrophy and black hair follicular dysplasia Acta Veterinaria Scandinavica 42:323-329, 2001. Pubmed reference: 11887392 .|
|2000||Verde, M.T., Basurco, A. :|
|Symmetrical lupoid onychodystrophy in a crossbred pointer dog: long-term observations Veterinary Record 146:376-378, 2000. Pubmed reference: 10803984 .|
|1995||Scott, D.W., Rousselle, S., Miller, W.H. :|
|Symmetrical lupoid onychodystrophy in dogs: A retrospective analysis of 18 cases (1989-1993) Journal of the American Animal Hospital Association 31:194-201, 1995. Pubmed reference: 7634051 .|
- Created by Frank Nicholas on 11 Apr 2016
- Changed by Frank Nicholas on 18 Oct 2016
- Changed by Frank Nicholas on 20 Sep 2019
- Changed by Imke Tammen2 on 12 Feb 2022