OMIA:002012-9615 : Glioma susceptibility in Canis lupus familiaris (dog) |
In other species: pig , northern tree shrew
Categories: Neoplasm
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 137800 (trait) , 613028 (trait) , 613029 (trait) , 607248 (trait) , 613030 (trait) , 613031 (trait) , 613032 (trait) , 613033 (trait) , 616568 (trait)
Mendelian trait/disorder: unknown
Disease-related: yes
Species-specific description: Truvé et al. (2016): "Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of developing glioma, but others, including Pug and Pekingese, are not at higher risk."
Mapping: "an across-breed genome-wide association study (GWAS) was performed on 39 dog glioma cases and 141 controls from 25 dog breeds, identifying a genome-wide significant locus on canine chromosome (CFA) 26 (p = 2.8 x 10−8)." (Truvé et al., 2016)
Molecular basis: Truvé et al. (2016) "identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease. Thus, one or more of these genes appear to affect glioma susceptibility."
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002012-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Dos Santos, E.C., Summers, B.A., Elbert, J.A., Miller, D.M., Rissi, D.R. : |
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| Molín, J., José-López, R., Ramírez, G.A., Pumarola, M. : | |
| Immunohistochemical expression of PTEN in canine gliomas. Animals (Basel) 14:2115, 2024. Pubmed reference: 39061577. DOI: 10.3390/ani14142115. | |
| Rissi, D.R., Reyes, V.A.A., Donovan, T.A., Church, M.E., Howerth, E.W., Klang, A., Woolard, K.D., Miller, A.D. : | |
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| 2023 | Garcia-Mora, J., Parker, R.L., Cecere, T., Robertson, J.L., Rossmeisl, J.H. : |
| The T2-FLAIR mismatch sign as an imaging biomarker for oligodendrogliomas in dogs. J Vet Intern Med 37:1447-1454, 2023. Pubmed reference: 37246729. DOI: 10.1111/jvim.16749. | |
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| Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med 55:725-734, 2023. Pubmed reference: 37009802. DOI: 10.1038/s12276-023-00977-3. | |
| Reyes, V.A.A., Howerth, E.W., Blas-Machado, U., Platt, S.R., Pavarini, S.P., Castro, L.T., Church, M.E., Rissi, D.R. : | |
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| 2022 | Krane, G.A., Shockley, K.R., Malarkey, D.E., Miller, A.D., Miller, C.R., Tokarz, D.A., Jensen, H.L., Janardhan, K.S., Breen, M., Mariani, C.L. : |
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| 2021 | Hicks, W.H., Bird, C.E., Pernik, M.N., Haider, A.S., Dobariya, A., Abdullah, K.G., Aoun, S.G., Bentley, R.T., Cohen-Gadol, A.A., Bachoo, R.M., Mickey, B.E., Pascual, J.M., El Ahmadieh, T.Y. : |
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| LeBlanc, A.K., Mazcko, C.N. : | |
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| 2019 | LeBlanc, A. : |
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| 2018 | Hubbard, M.E., Arnold, S., Bin Zahid, A., McPheeters, M., Gerard O'Sullivan, M., Tabaran, A.F., Hunt, M.A., Pluhar, G.E. : |
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| 2016 | Herranz, C., Fernández, F., Martín-Ibáñez, R., Blasco, E., Crespo, E., De la Fuente, C., Añor, S., Rabanal, R.M., Canals, J.M., Pumarola, M. : |
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| 2013 | Song, R.B., Vite, C.H., Bradley, C.W., Cross, J.R. : |
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Edit History
- Created by Frank Nicholas on 19 May 2016
- Changed by Frank Nicholas on 19 May 2016
- Changed by Imke Tammen2 on 08 Nov 2021
- Changed by Imke Tammen2 on 12 Sep 2022