OMIA:002060-9541 : Adrenal hypoplasia, congenital in Macaca fascicularis (crab-eating macaque) |
Categories: Reproductive system phene , Endocrine / exocrine gland phene (incl mammary gland)
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 300200 (trait) , 300473 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: yes
Key variant known: no
Species-specific description: This disorder has been created artificially by CRISPR/Cas9; it is a genetically-modified organism (GMO)
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| NR0B1 | nuclear receptor subfamily 0 group B member 1 | Macaca fascicularis | X | NC_088395.1 (30319212..30313777) | NR0B1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002060-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2015 | Kang, Y., Zheng, B., Shen, B., Chen, Y., Wang, L., Wang, J., Niu, Y., Cui, Y., Zhou, J., Wang, H., Guo, X., Hu, B., Zhou, Q., Sha, J., Ji, W., Huang, X. : |
| CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Hum Mol Genet 24:7255-64, 2015. Pubmed reference: 26464492. DOI: 10.1093/hmg/ddv425. |
Edit History
- Created by Frank Nicholas on 18 Oct 2016
- Changed by Imke Tammen2 on 29 Sep 2023
- Changed by Imke Tammen2 on 18 Dec 2023