OMIA:002074-9940 : Tail, fat in Ovis aries (sheep) |
Categories: Limbs / fins / digit / tail phene
Single-gene trait/disorder: no
Mode of inheritance: Multifactorial
Disease-related: no
Key variant known: yes
Year key variant first reported: 2024
Mapping: Pan et al. (2019): "Our findings suggest the fixation of fat tails in domestic sheep is caused by a selective sweep near a retro-transposable hotspot at chromosome 13, the diversity of which specifically affects the expression of BMP2" Dong et al. (2020) "used an extended data set of 968 sheep representing 18 fat-tailed breeds and 14 thin-tailed breeds from around the world, and integrated two statistical tests to detect selection signatures.... The results showed that platelet derived growth factor D (PDGFD) exhibited the highest genetic differentiation between fat- and thin-tailed sheep breeds. Analysis of sequence variation identified that a 6.8-kb region within the first intron of PDGFD is likely the target of positive selection and contains regulatory mutation(s) in fat-tailed sheep." Jin et al. (2022) performed RNA sequencing on Hu and Tibetan sheep. "Eight genes were selected for validation by RT-qPCR. ... results showed that significant genes (BMP2, HOXA11, PPP1CC and LPIN1) are involved in the regulation of adipogenesis metabolism and suggested novel insights into metabolic molecules in sheep fat tails." Kalds et al. (2023) "utilized base-editing technology to generate PDGFD-edited sheep, highlighting its potential involvement in the sheep tail configuration." (GMO)
Molecular basis: Zhang et al. (2024) “through integrated analysis of selection signatures, GWAS results, epigenomic data of tail fat tissue, and RNA‐seq data, we found the A allele of Chr13:51760995A>C to be … associated with lower tail fat weight and decreased BMP2 expression in tail fat tissues. … Our functional verification results confirmed that BMP2 overexpression can increase adipogenic potential, but its inhibited expression prevents adipogenesis.”
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| BMP2 | bone morphogenetic protein 2 | Ovis aries | 13 | NC_056066.1 (48877314..48889861) | BMP2 | Homologene, Ensembl , NCBI gene |
Variants
By default, variants are sorted chronologically by year of publication, to provide a historical perspective.
Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending
order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column
headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Type of Variant | Source of Genetic Variant | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1768 | Tail fat deposition | BMP2 | regulatory | Naturally occurring variant | ARS-UI_Ramb_v1.0 | 13 | NC_040264.1:g.51760995A>C | candidate causal variant that influences tail fat weight trait and expression of BMP2 | 2024 | 39742295 |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002074-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Da Silva, A., Ahbara, A., Baazaoui, I., Jemaa, S.B., Cao, Y., Ciani, E., Dzomba, E.F., Evans, L., Gootwine, E., Hanotte, O., Harris, L., Li, M.H., Mastrangelo, S., Missohou, A., Molotsi, A., Muchadeyi, F.C., Mwacharo, J.M., Tallet, G., Vernus, P., Hall, S.J.G., Lenstra, J.A. : |
| History and genetic diversity of African sheep: Contrasting phenotypic and genomic diversity. Anim Genet 56:e13488, 2025. Pubmed reference: 39561986. DOI: 10.1111/age.13488. | |
| 2024 | Abbasabadi, H., Bakhtiarizadeh, M.R., Moradi, M.H., McEwan, J.C. : |
| RNA-Seq based selection signature analysis for identifying genomic footprints associated with the fat-tail phenotype in sheep. Front Vet Sci 11:1415027, 2024. Pubmed reference: 39403211. DOI: 10.3389/fvets.2024.1415027. | |
| Ben-Jemaa, S., Yahyaoui, G., Kdidi, S., Najjari, A., Lenstra, J.A., Mastrangelo, S., Gaouar, S.B.S., Mwacharo, J.M., Khorchani, T., Yahyaoui, M.H. : | |
| Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds. Anim Genet 56:e13487, 2024. Pubmed reference: 39573836. DOI: 10.1111/age.13487. | |
| Li, X., Zhu, L., Zhang, C.L., Wang, X., Li, Y., Zhou, W., Han, Z., Yang, R., Peng, Y., Han, Y., Zhang, L., Zheng, L., Liu, S. : | |
| Genetic structure and selective sweeps in Kirghiz sheep using SNP50K bead chip. Front Genet 15:1432105, 2024. Pubmed reference: 39233740. DOI: 10.3389/fgene.2024.1432105. | |
| Mansourizadeh, H., Bakhtiarizadeh, M.R., de Almeida Regitano, L.C., Bruscadin, J.J. : | |
| Fat-tail allele-specific expression genes may affect fat deposition in tail of sheep. PLoS One 19:e0316046, 2024. Pubmed reference: 39729475. DOI: 10.1371/journal.pone.0316046. | |
| Niu, Y., Li, Y., Zhao, Y., He, X., Zhao, Q., Pu, Y., Ma, Y., Jiang, L. : | |
| Whole-genome sequencing identifies functional genes for environmental adaptation in Chinese sheep. J Genet Genomics 51:1278-1285, 2024. Pubmed reference: 39260683. DOI: 10.1016/j.jgg.2024.08.011. | |
| Qi, Y., He, X., Wang, B., Yang, C., Da, L., Liu, B., Zhang, W., Fu, S., Liu, Y. : | |
| Selection signature analysis reveals genes associated with tail phenotype in sheep. Front Genet 15:1509177, 2024. Pubmed reference: 39722798. DOI: 10.3389/fgene.2024.1509177. | |
| Zhang, D., Cheng, J., Li, X., Huang, K., Yuan, L., Zhao, Y., Xu, D., Zhang, Y., Zhao, L., Yang, X., Ma, Z., Xu, Q., Li, C., Wang, X., Zheng, C., Tang, D., Nian, F., Yue, X., Li, W., Tian, H., Weng, X., Hu, P., Feng, Y., Kalds, P., Jiang, Z., Zhao, Y., Zhang, X., Li, F., Wang, W. : | |
| Comprehensive multi-tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding. Imeta 3:e254, 2024. Pubmed reference: 39742295. DOI: 10.1002/imt2.254. | |
| Zhao, F., Xie, R., Fang, L., Xiang, R., Yuan, Z., Liu, Y., Wang, L. : | |
| Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep. Evol Appl 17:e13697, 2024. Pubmed reference: 38911262. DOI: 10.1111/eva.13697. | |
| 2023 | Kalds, P., Huang, S., Xi, S., Fang, Y., Gao, Y., Zhou, S., Sun, K., Li, C., Cai, B., Liu, Y., Ding, Y., Kou, Q., Sonstegard, T., Petersen, B., Kemp, S., Ma, B., Han, J.L., Chen, Y., Wang, X. : |
| ABE-induced PDGFD start codon silencing unveils new insights into the genetic architecture of sheep fat tails. J Genet Genomics 50:1022-1025, 2023. Pubmed reference: 37516349. DOI: 10.1016/j.jgg.2023.07.008. | |
| 2022 | Jin, M., Fei, X., Li, T., Lu, Z., Chu, M., Di, R., He, X., Wang, X., Wei, C. : |
| Transcriptome study digs out BMP2 involved in adipogenesis in sheep tails. BMC Genomics 23:457, 2022. Pubmed reference: 35725366. DOI: 10.1186/s12864-022-08657-8. | |
| 2021 | Kalds, P., Luo, Q., Sun, K., Zhou, S., Chen, Y., Wang, X. : |
| Trends towards revealing the genetic architecture of sheep tail patterning: Promising genes and investigatory pathways. Anim Genet 52:799-812, 2021. Pubmed reference: 34472112. DOI: 10.1111/age.13133. | |
| Salehian-Dehkordi, H., Xu, Y.X., Xu, S.S., Li, X., Luo, L.Y., Liu, Y.J., Wang, D.F., Cao, Y.H., Shen, M., Gao, L., Chen, Z.H., Glessner, J.T., Lenstra, J.A., Esmailizadeh, A., Li, M.H., Lv, F.H. : | |
| Genome-wide detection of copy number variations and their association with distinct phenotypes in the world's sheep. Front Genet 12:670582, 2021. Pubmed reference: 34093663. DOI: 10.3389/fgene.2021.670582. | |
| 2020 | Amane, A., Belay, G., Nasser, Y., Kyalo, M., Dessie, T., Kebede, A., Getachew, T., Entfellner, J.D., Edea, Z., Hanotte, O., Tarekegn, G.M. : |
| Genome-wide insights of Ethiopian indigenous sheep populations reveal the population structure related to tail morphology and phylogeography. Genes Genomics 42:1169-1178, 2020. Pubmed reference: 32803704. DOI: 10.1007/s13258-020-00984-y. | |
| Dong, K., Yang, M., Han, J., Ma, Q., Han, J., Song, Z., Luosang, C., Gorkhali, N.A., Yang, B., He, X., Ma, Y., Jiang, L. : | |
| Genomic analysis of worldwide sheep breeds reveals PDGFD as a major target of fat-tail selection in sheep. BMC Genomics 21:800, 2020. Pubmed reference: 33203382. DOI: 10.1186/s12864-020-07210-9. | |
| Li, X., Yang, J., Shen, M., Xie, X.L., Liu, G.J., Xu, Y.X., Lv, F.H., Yang, H., Yang, Y.L., Liu, C.B., Zhou, P., Wan, P.C., Zhang, Y.S., Gao, L., Yang, J.Q., Pi, W.H., Ren, Y.L., Shen, Z.Q., Wang, F., Deng, J., Xu, S.S., Salehian-Dehkordi, H., Hehua, E., Esmailizadeh, A., Dehghani-Qanatqestani, M., Štěpánek, O., Weimann, C., Erhardt, G., Amane, A., Mwacharo, J.M., Han, J.L., Hanotte, O., Lenstra, J.A., Kantanen, J., Coltman, D.W., Kijas, J.W., Bruford, M.W., Periasamy, K., Wang, X.H., Li, M.H. : | |
| Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nat Commun 11:2815, 2020. Pubmed reference: 32499537. DOI: 10.1038/s41467-020-16485-1. | |
| Zhao, F., Deng, T., Shi, L., Wang, W., Zhang, Q., Du, L., Wang, L. : | |
| Genomic scan for selection signature reveals fat deposition in Chinese indigenous sheep with extreme tail types. Animals (Basel) 10:773, 2020. Pubmed reference: 32365604. DOI: 10.3390/ani10050773. | |
| 2019 | Pan, Z., Li, S., Liu, Q., Wang, Z., Zhou, Z., Di, R., An, X., Miao, B., Wang, X., Hu, W., Guo, X., Lv, S., Li, F., Ding, G., Chu, M., Li, Y. : |
| Rapid evolution of a retro-transposable hotspot of ovine genome underlies the alteration of BMP2 expression and development of fat tails. BMC Genomics 20:261, 2019. Pubmed reference: 30940097. DOI: 10.1186/s12864-019-5620-6. | |
| Zhang, T., Gao, H., Sahana, G., Zan, Y., Fan, H., Liu, J., Shi, L., Wang, H., Du, L., Wang, L., Zhao, F. : | |
| Genome-wide association studies revealed candidate genes for tail fat deposition and body size in the Hulun Buir sheep. J Anim Breed Genet 136:362-370, 2019. Pubmed reference: 31045295. DOI: 10.1111/jbg.12402. | |
| 2018 | Ahbara, A., Bahbahani, H., Almathen, F., Al Abri, M., Agoub, M.O., Abeba, A., Kebede, A., Musa, H.H., Mastrangelo, S., Pilla, F., Ciani, E., Hanotte, O., Mwacharo, J.M. : |
| Genome-wide variation, candidate regions and genes associated with fat deposition and tail morphology in Ethiopian indigenous sheep. Front Genet 9:699, 2018. Pubmed reference: 30687385. DOI: 10.3389/fgene.2018.00699. | |
| 2017 | Xu, S.S., Ren, X., Yang, G.L., Xie, X.L., Zhao, Y.X., Zhang, M., Shen, Z.Q., Ren, Y.L., Gao, L., Shen, M., Kantanen, J., Li, M.H. : |
| Genome-wide association analysis identifies the genetic basis of fat deposition in the tails of sheep (Ovis aries). Anim Genet 48:560-569, 2017. Pubmed reference: 28677334. DOI: 10.1111/age.12572. | |
| 2016 | Jafari, S., Razzagzadeh, S. : |
| Genetic analysis and the estimates of genetic and phenotypic correlation of growth rates, Kleiber ratios, and fat-tail dimensions with birth to yearling live body weight traits in Makuie sheep. Trop Anim Health Prod 48:667-72, 2016. Pubmed reference: 26739342. DOI: 10.1007/s11250-015-0987-0. | |
| Liu, Z., Ji, Z., Wang, G., Chao, T., Hou, L., Wang, J. : | |
| Genome-wide analysis reveals signatures of selection for important traits in domestic sheep from different ecoregions. BMC Genomics 17:863, 2016. Pubmed reference: 27809776. DOI: 10.1186/s12864-016-3212-2. | |
| Yuan, Z., Liu, E., Liu, Z., Kijas, J.W., Zhu, C., Hu, S., Ma, X., Zhang, L., Du, L., Wang, H., Wei, C. : | |
| Selection signature analysis reveals genes associated with tail type in Chinese indigenous sheep. Anim Genet 48:55-66, 2016. Pubmed reference: 27807880. DOI: 10.1111/age.12477. | |
| Yue, Y., Cheng, X., Zhao, S.G., Liu, Z., Liu, L.S., Zhou, R., Wu, J.P., Brown, M.A. : | |
| Effects of tail docking on the expression of genes related to lipid metabolism in Lanzhou fat-tailed sheep. Genet Mol Res 15, 2016. Pubmed reference: 27050972. DOI: 10.4238/gmr.15017323. | |
| Zhu, C., Fan, H., Yuan, Z., Hu, S., Ma, X., Xuan, J., Wang, H., Zhang, L., Wei, C., Zhang, Q., Zhao, F., Du, L. : | |
| Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays. Sci Rep 6:27822, 2016. Pubmed reference: 27282145. DOI: 10.1038/srep27822. | |
| 2015 | Hajihosseinlo, A., Jafari, S., Ajdary, M. : |
| The relationship of GH and LEP gene polymorphisms with fat-tail measurements (fat-tail dimensions) in fat-tailed Makooei breed of Iranian sheep. Adv Biomed Res 4:172, 2015. Pubmed reference: 26605211. DOI: 10.4103/2277-9175.163995. | |
| Moioli, B., Pilla, F., Ciani, E. : | |
| Signatures of selection identify loci associated with fat tail in sheep. J Anim Sci 93:4660-9, 2015. Pubmed reference: 26523558. DOI: 10.2527/jas.2015-9389. | |
| Xu, X.C., Li, B.B., Wei, X., Yang, Y.X., Wang, X.L., Chen, Y.L. : | |
| Differential expression of peroxisome proliferator-activated receptor γ, fatty acid synthase, and hormone-sensitive lipase in fat-tailed and thin-tailed sheep breeds. Genet Mol Res 14:15624-33, 2015. Pubmed reference: 26634530. DOI: 10.4238/2015.December.1.14. | |
| 2013 | Gan, S.Q., Zhang, W., Shen, M., Li, H., Yang, J.Q., Liang, Y.W., Gao, L., Liu, S.R., Wang, X.H. : |
| [Correlation analysis between polymorphism of the 59383635th locus on X chromosome and fat-tail trait in sheep]. Yi Chuan 35:1209-16, 2013. Pubmed reference: 24459894. DOI: 10.3724/sp.j.1005.2013.01209. | |
| 2012 | Moradi, M.H., Nejati-Javaremi, A., Moradi-Shahrbabak, M., Dodds, K.G., McEwan, J.C. : |
| Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition. BMC Genet 13:10, 2012. Pubmed reference: 22364287. DOI: 10.1186/1471-2156-13-10. |
Edit History
- Created by Frank Nicholas on 09 Nov 2016
- Changed by Frank Nicholas on 21 Sep 2019
- Changed by Imke Tammen2 on 01 Dec 2020
- Changed by Imke Tammen2 on 28 Nov 2022
- Changed by Imke Tammen2 on 01 Aug 2023
- Changed by Imke Tammen2 on 04 Jan 2025