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OMIA:002077-9031 : Body weight in Gallus gallus (chicken)

In other species: dog , pig , taurine cattle , sheep

Categories: Growth / size / body region phene

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Disease-related: no

Key variant known: yes

Year key variant first reported: 2016

Molecular basis: Jia et al. (2016): "a 54-bp insertion mutation in the upstream region of miR-15a-16 . . . resulted in lower miR-16 expression by introducing three novel splicing sites instead of the missing 5′ terminal splicing of mature miR-16. Elevating miR-16 significantly inhibited DF-1 chicken embryo cell proliferation, consistent with a role in suppression of cellular growth."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MIR15A microRNA 15a Gallus gallus 1 NC_052532.1 (169278486..169278404) MIR15A Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2016). OMIA:002077-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2016 Jia, X., Lin, H., Nie, Q., Zhang, X., Lamont, S.J. :
A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken. Sci Rep 6:36433, 2016. Pubmed reference: 27808177. DOI: 10.1038/srep36433.

Edit History


  • Created by Frank Nicholas on 18 Nov 2016
  • Changed by Frank Nicholas on 18 Nov 2016