OMIA 002170-9913 : Oligosaccharide content in Bos taurus

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: no

Key variant known: no

Genetic testing: Following a GWAS for "the abundance of 12 major OS [oligosaccharides] in milk of 360 cows, which had high density SNP marker genotypes", Liu et al. (2019) identified two variants of large effect: "a putative causal mutation close to the ABO gene on Chromosome 11 accounted for approximately 80% of genetic variance for two OS, N-acetylgalactosaminyllactose and lacto-N-neotetraose. This mutation lies very close to a variant associated with the expression levels of ABO. A third QTL mapped close to ST3GAL6 on Chromosome 1 explaining 33% of genetic variation of an abundant OS, 3'-sialyllactose."

Reference


2019 Liu, Z., Wang, T., Pryce, J.E., MacLeod, I.M., Hayes, B.J., Chamberlain, A.J., Jagt, C.V., Reich, C.M., Mason, B.A., Rochfort, S., Cocks, B.G. :
Fine-mapping sequence mutations with a major effect on oligosaccharide content in bovine milk. Sci Rep 9:2137, 2019. Pubmed reference: 30765736. DOI: 10.1038/s41598-019-38488-9.

Edit History


  • Created by Frank Nicholas on 27 Feb 2019
  • Changed by Frank Nicholas on 27 Feb 2019