OMIA 002204-9378 : Leptin deficiency or dysfunction in Suncus murinus

Possibly relevant human trait(s) and/or gene(s) (MIM number): 614962

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Saga et al. (2019) reported an "Insertion of the three aa, VPQ, not seen in other mammals" in the house musk shrew leptin peptide, leading them to suggest "the possibility of [the house musk shrew] being a model of human lipodystrophy"

Reference


2019 Saga, S., Sasaki, N., Arai, T. :
Molecular identification, characterization, and structure analysis of house musk shrew (<i>Suncus murinus</i>) leptin. J Adv Vet Anim Res 6:1-8, 2019. Pubmed reference: 31453164. DOI: 10.5455/javar.2019.f305.

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  • Created by Frank Nicholas on 05 Sep 2019