OMIA:002204-9378 : Leptin deficiency or dysfunction in Suncus murinus (house shrew)
Categories: Homeostasis / metabolism phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 614962 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Saga et al. (2019) reported an "Insertion of the three aa, VPQ, not seen in other mammals" in the house musk shrew leptin peptide, leading them to suggest "the possibility of [the house musk shrew] being a model of human lipodystrophy"
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
|2019||Saga, S., Sasaki, N., Arai, T. :|
|Molecular identification, characterization, and structure analysis of house musk shrew (<i>Suncus murinus</i>) leptin. J Adv Vet Anim Res 6:1-8, 2019. Pubmed reference: 31453164. DOI: 10.5455/javar.2019.f305.|
- Created by Frank Nicholas on 05 Sep 2019