OMIA:002204-9378 : Leptin deficiency or dysfunction in Suncus murinus (house shrew)

Categories: Homeostasis / metabolism phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 614962 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Saga et al. (2019) reported an "Insertion of the three aa, VPQ, not seen in other mammals" in the house musk shrew leptin peptide, leading them to suggest "the possibility of [the house musk shrew] being a model of human lipodystrophy"

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2019). OMIA:002204-9378: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2019 Saga, S., Sasaki, N., Arai, T. :
Molecular identification, characterization, and structure analysis of house musk shrew (<i>Suncus murinus</i>) leptin. J Adv Vet Anim Res 6:1-8, 2019. Pubmed reference: 31453164. DOI: 10.5455/javar.2019.f305.

Edit History

  • Created by Frank Nicholas on 05 Sep 2019