OMIA 002209-7950 : Adaptation to a red-shifted light environment in Clupea harengus

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2019

Molecular basis: Hill et al. (2019): "Atlantic herring . . . colonized the brackish Baltic Sea within the last 10,000 y." Being less salty, the Baltic Sea contains more "dissolved organic matter [that] produces a red-shifted visual environment compared with marine waters." The authors "show that visual adaptation to the new light environment was achieved through a recent and rapid selective sweep on a [missense] mutation [Phe261Tyr] in the rhodopsin gene. Furthermore, this exact same amino acid change has occurred at least 20 separate times in fish species transitioning from marine to brackish or freshwater environments. This is a remarkable example of convergent evolution."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
rho rhodopsin Clupea harengus 1 NC_045152.1 (27341179..27338919) rho Homologene, Ensembl, NCBI gene

Variants

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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Adaptation to a red-shifted light environment rho missense p.Phe261Tyr 2019 31451650

Reference


2019 Hill, J., Enbody, E.D., Pettersson, M.E., Sprehn, C.G., Bekkevold, D., Folkvord, A., Laikre, L., Kleinau, G., Scheerer, P., Andersson, L. :
Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin. Proc Natl Acad Sci U S A :, 2019. Pubmed reference: 31451650. DOI: 10.1073/pnas.1908332116.

Edit History


  • Created by Frank Nicholas on 13 Sep 2019
  • Changed by Frank Nicholas on 13 Sep 2019