OMIA:002291-9615 : Maxillary canine-tooth mesioversion in Canis lupus familiaris
Categories: Skeleton phene (incl. short stature & teeth)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Mapping: Abrams et al. (2020) "conducted independent genomewide association studies in the small Shetland Sheepdog breed and discovered a locus on chromosome 9 that is associated with a dental abnormality called maxillary canine-tooth mesioversion (MCM) (P = 1.53 × 10−7) as well as two body size traits: height (P = 1.67 × 10−5) and weight (P = 1.16 × 10−7)"
Markers: Abrans et al. (2020): "Using whole-genome resequencing data, we identified variants in two proximal genes: FTSJ3, encoding an RNA methyltransferase, and GH1, encoding growth hormone. A substitution in FTSJ3 and a splice donor insertion in GH1 are strongly associated with MCM and reduced body size in Shetland Sheepdogs".
Clinical features: Abrams et al. 92020): "maxillary canine-tooth mesioversion (MCM) describes an upper canine tooth that is displaced forward toward the nose, also known as a lance canine . . . . One or both maxillary canines may be affected. MCM can cause traumatic occlusion, ulceration of the upper lip, and/or periodontal disease and may require extraction or orthodontic repositioning".
Breed: Shetland Sheepdog.
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2020||Abrams, S.R., Hawks, A.L., Evans, J.M., Famula, T.R., Mahaffey, M., Johnson, G.S., Mason, J.M., Clark, L.A. :|
|Variants in FtsJ RNA 2'-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proc Natl Acad Sci U S A 117:24929-24935, 2020. Pubmed reference: 32958658 . DOI: 10.1073/pnas.2009500117.|
|2008||Legendre, L., Stepaniuk, K. :|
|Correction of maxillary canine tooth mesioversion in dogs. J Vet Dent 25:216-21, 2008. Pubmed reference: 19025142 . DOI: 10.1177/089875640802500312.|
- Created by Frank Nicholas on 26 Oct 2020
- Changed by Frank Nicholas on 26 Oct 2020
- Changed by Imke Tammen2 on 28 Oct 2022