OMIA:002312-9031 : Sterile, female, DDX4-related in Gallus gallus
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 605281 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: yes
Key variant known: no
Species-specific description: Taylor et al. (2017) "use TALE nucleases (TALENs) to target a reporter construct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs). ... . The targeted PGCs were germline competent and were used to produce DDX4 null offspring. In DDX4 knockout chickens, PGCs are initially formed but are lost during meiosis in the developing ovary, leading to adult female sterility." These are genetically-modified organisms (GMO).
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|DDX4||DEAD (Asp-Glu-Ala-Asp) box polypeptide 4||Gallus gallus||Z||NC_052572.1 (17471887..17503681)||DDX4||Homologene, Ensembl , NCBI gene|
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Ballantyne, M., Woodcock, M., Doddamani, D., Hu, T., Taylor, L., Hawken, R.J., McGrew, M.J. :|
|Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating. Nat Commun 12:659, 2021. Pubmed reference: 33510156 . DOI: 10.1038/s41467-020-20812-x.|
|2019||Woodcock, M.E., Gheyas, A.A., Mason, A.S., Nandi, S., Taylor, L., Sherman, A., Smith, J., Burt, D.W., Hawken, R., McGrew, M.J. :|
|Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds. Proc Natl Acad Sci U S A 116:20930-20937, 2019. Pubmed reference: 31575742 . DOI: 10.1073/pnas.1906316116.|
|2017||Taylor, L., Carlson, D.F., Nandi, S., Sherman, A., Fahrenkrug, S.C., McGrew, M.J. :|
|Efficient TALEN-mediated gene targeting of chicken primordial germ cells. Development 144:928-934, 2017. Pubmed reference: 28174243 . DOI: 10.1242/dev.145367.|
- Created by Imke Tammen2 on 18 Feb 2021
- Changed by Imke Tammen2 on 18 Feb 2021