OMIA 002312-9031 : sterile, female-DDX4 related in Gallus gallus

Possibly relevant human trait(s) and/or gene(s) (MIM number): 605281 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific description: Taylor et al. (2017) "use TALE nucleases (TALENs) to target a reporter construct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs). ... . The targeted PGCs were germline competent and were used to produce DDX4 null offspring. In DDX4 knockout chickens, PGCs are initially formed but are lost during meiosis in the developing ovary, leading to adult female sterility." These are genetically-modified organisms (GMO).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 Gallus gallus Z NC_052572.1 (17471887..17503681) DDX4 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Ballantyne, M., Woodcock, M., Doddamani, D., Hu, T., Taylor, L., Hawken, R.J., McGrew, M.J. :
Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating. Nat Commun 12:659, 2021. Pubmed reference: 33510156. DOI: 10.1038/s41467-020-20812-x.
2019 Woodcock, M.E., Gheyas, A.A., Mason, A.S., Nandi, S., Taylor, L., Sherman, A., Smith, J., Burt, D.W., Hawken, R., McGrew, M.J. :
Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds. Proc Natl Acad Sci U S A 116:20930-20937, 2019. Pubmed reference: 31575742. DOI: 10.1073/pnas.1906316116.
2017 Taylor, L., Carlson, D.F., Nandi, S., Sherman, A., Fahrenkrug, S.C., McGrew, M.J. :
Efficient TALEN-mediated gene targeting of chicken primordial germ cells. Development 144:928-934, 2017. Pubmed reference: 28174243. DOI: 10.1242/dev.145367.

Edit History


  • Created by Imke Tammen2 on 18 Feb 2021
  • Changed by Imke Tammen2 on 18 Feb 2021