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OMIA:002351-9796 : Transmission ratio distortion in Equus caballus (horse)

In other species: turkey , taurine cattle , indicine cattle (zebu)

Categories: Reproductive system phene , Mortality / aging (incl. embryonic lethal)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Deviation from Mendelian inheritance expectations / transmission ratio distortion (TDR) identified in the analysis of single nucleotide polymorphism data. Identified haplotypes with homozygous deficiency can indicate the presence of (embryonic) recessive lethal or semi-lethal alleles in a population.

Mapping: Laseca et al. (2023): "A total of 1,041 Pura Raza Español breed horses were genotyped with 554,634 SNPs. Among them, 277 horses genotyped in trios (stallion-mare-offspring) were used to perform the TRD analysis. Our results revealed 140 and 42 SNPs with allelic and genotypic patterns, respectively. Among them, 63 displayed stallion-TRD and 41 exhibited mare-TRD, while 36 SNPs showed overall TRD. In addition, 42 SNPs exhibited heterosis pattern. Functional analyses revealed that the annotated genes located within the TRD regions identified were associated with biological processes and molecular functions related to spermatogenesis, oocyte division, embryonic development, and hormonal activity."

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002351-9796: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Laseca, N., Cánovas, Á., Valera, M., Id-Lahoucine, S., Perdomo-González, D.I., Fonseca, P.A.S., Demyda-Peyrás, S., Molina, A. :
Genomic screening of allelic and genotypic transmission ratio distortion in horse. PLoS One 18:e0289066, 2023. Pubmed reference: 37556504. DOI: 10.1371/journal.pone.0289066.
Perdomo-González, D.I., Id-Lahoucine, S., Molina, A., Cánovas, A., Laseca, N., Azor, P.J., Valera, M. :
Transmission ratio distortion detection by neutral genetic markers in the Pura Raza Española horse breed. Animal 17:S1751-7311(23)00329-4:101012, 2023. Pubmed reference: 37950978. DOI: 10.1016/j.animal.2023.101012.

Edit History


  • Created by Imke Tammen2 on 19 Aug 2023
  • Changed by Imke Tammen2 on 19 Aug 2023