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OMIA:002379-9483 : Parkinson disease, LRRK2-related in Callithrix jacchus (white-tufted-ear marmoset)

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 609007 (gene) , 607060 (trait)

Mendelian trait/disorder: unknown

Disease-related: yes

Species-specific description: This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
LRRK2 leucine rich repeat kinase 2 Callithrix jacchus 9 NC_071450.1 (31939914..31786235) LRRK2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002379-9483: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Khan, E., Hasan, I., Haque, M.E. :
Parkinson's disease: Exploring different animal model systems. Int J Mol Sci 24:9088, 2023. Pubmed reference: 37240432. DOI: 10.3390/ijms24109088.
2020 Vermilyea, S.C., Babinski, A., Tran, N., To, S., Guthrie, S., Kluss, J.H., Schmidt, J.K., Wiepz, G.J., Meyer, M.G., Murphy, M.E., Cookson, M.R., Emborg, M.E., Golos, T.G. :
In vitro CRISPR/Cas9-directed gene editing to model LRRK2 G2019S Parkinson's disease in common marmosets. Sci Rep 10:3447, 2020. Pubmed reference: 32103062. DOI: 10.1038/s41598-020-60273-2.

Edit History


  • Created by Imke Tammen2 on 11 Aug 2021
  • Changed by Imke Tammen2 on 18 Dec 2023