In other species: green monkey

Categories: Vision / eye phene

Mendelian trait/disorder: unknown

Disease-related: yes

Cross-species summary: The vitreous body is the largest structure of the eye. Deterioration of collagen and hyaluronic acid in the vitreous can lead to vitreous degeneration, which may predispose to retinal detachment resulting in blindness.

Species-specific description: Krishnan et al. (2019) reported "a retrospective study of 4217 dogs from the Companion Animal Eye Registry (CAER) that underwent breed screening ophthalmic examinations between 2013 and 2016. The breeds analyzed included the Italian Greyhound, Shih Tzu, Affenpinscher, Bichon Frise, Brussels Griffon, Whippets, and Greyhound. Data collected from CAER included age, gender, number of examinations, and whether vitreous degeneration, along with cataracts, lens luxation, glaucoma and/or retinal detachment were present in either or both eyes. ... The study found that breed and age are significant drivers for developing VD. Italian Greyhounds, Brussels Griffons, and Shih Tzus have a significantly higher likelihood of VD compared to the negative control breed, the Greyhound. ... However, no association was identified between vitreous degeneration and cataracts, lens luxation, glaucoma, or retinal detachment."

Breeds: Brussels Griffon (Dog) (VBO_0200241), Italian Greyhound (Dog) (VBO_0200713), Shih Tzu (Dog) (VBO_0201223).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).