OMIA:002421-9685 : Drug metabolism, altered in Felis catus (domestic cat) |
In other species: dog , pig , sheep
Categories: Homeostasis / metabolism phene
Single-gene trait/disorder: unknown
Disease-related: unknown
Markers: Ueda et al. (2021) "assessed the impact of single nucleotide polymorphisms (SNPs) within ADP receptor (P2RY1, P2RY12) and cytochrome P450 isoenzyme (CYP2C41) genes on platelet inhibition by clopidogrel administration in cats with HCM [hypertrophic cardiomyopathy] ... [and] demonstrated that a genetic polymorphism in the P2RY1 gene altered response to clopidogrel therapy and suggests that clinicians may consider alternative or additional thromboprophylactic therapy in cats with the P2RY1:A236G variant."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| P2RY1 | purinergic receptor P2Y1 | Felis catus | C2 | NC_058376.1 (111305991..111299898) | P2RY1 | Ensembl, NCBI gene |
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2025). OMIA:002421-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2025 | Yeh, N.S., Shaverdian, M., Li, R.H.L. : |
| Evolving FATE: A new lens on the pathogenesis and management of feline cardiogenic arterial thromboembolism. Animals (Basel) 15:1630, 2025. Pubmed reference: 40509097. DOI: 10.3390/ani15111630. | |
| 2024 | Vaidhya, A., Ghildiyal, K., Rajawat, D., Nayak, S.S., Parida, S., Panigrahi, M. : |
| Relevance of pharmacogenetics and pharmacogenomics in veterinary clinical practice: A review. Anim Genet 55:3-19, 2024. Pubmed reference: 37990577. DOI: 10.1111/age.13376. | |
| 2021 | Ueda, Y., Li, R.H.L., Nguyen, N., Ontiveros, E.S., Kovacs, S.L., Oldach, M.S., Vernau, K.M., Court, M.H., Stern, J.A. : |
| A genetic polymorphism in P2RY1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy. Sci Rep 11:12522, 2021. Pubmed reference: 34131167. DOI: 10.1038/s41598-021-91372-3. |
Edit History
- Created by Imke Tammen2 on 07 Sep 2024
- Changed by Imke Tammen2 on 17 Jun 2025