OMIA:002467-9823 : Muscle growth, IGF2-related in Sus scrofa (pig)

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 147470 (gene) , 616489 (trait)

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Molecular basis: Ren et al. (2024) “generated porcine fibroblasts with simultaneous knockouts of IGF2, ANPEP, CD163, and MSTN via Cas12iMax in one step. Phenotypically stable pigs were created through somatic cell nuclear transfer technology. They exhibited improved growth performance and muscle quality.” This study involves genetically modified organisms (GMO)

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
IGF2 insulin-like growth factor 2 Sus scrofa 2 NC_010444.4 (1496417..1469183) IGF2 Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002467-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Ren, J., Hai, T., Chen, Y., Sun, K., Han, Z., Wang, J., Li, C., Wang, Q., Wang, L., Zhu, H., Yu, D., Li, W., Zhao, S. :
Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax. Sci China Life Sci 67:555-564, 2024. Pubmed reference: 37987939. DOI: 10.1007/s11427-023-2407-0.
2023 Duo, T., Liu, X., Mo, D., Bian, Y., Cai, S., Wang, M., Li, R., Zhu, Q., Tong, X., Liang, Z., Jiang, W., Chen, S., Chen, Y., He, Z. :
Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs. J Anim Sci Biotechnol 14:141, 2023. Pubmed reference: 37919760. DOI: 10.1186/s40104-023-00930-4.
2021 Wang, D., Pu, Y., Li, Y., Pan, D., Wang, S., Tian, W., Ma, Y., Jiang, L. :
Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs. BMC Genomics 22:593, 2021. Pubmed reference: 34348644. DOI: 10.1186/s12864-021-07881-y.
2019 Liu, X., Liu, H., Wang, M., Li, R., Zeng, J., Mo, D., Cong, P., Liu, X., Chen, Y., He, Z. :
Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs. Transgenic Res 28:141-150, 2019. Pubmed reference: 30488155. DOI: 10.1007/s11248-018-0107-9.
2018 Xiang, G., Ren, J., Hai, T., Fu, R., Yu, D., Wang, J., Li, W., Wang, H., Zhou, Q. :
Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs. Cell Mol Life Sci 75:4619-4628, 2018. Pubmed reference: 30259067. DOI: 10.1007/s00018-018-2917-6.
2012 Aslan, O., Hamill, R.M., Davey, G., McBryan, J., Mullen, A.M., Gispert, M., Sweeney, T. :
Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle. Mol Biol Rep 39:4101-10, 2012. Pubmed reference: 21779802. DOI: 10.1007/s11033-011-1192-5.
Burgos, C., Galve, A., Moreno, C., Altarriba, J., Reina, R., García, C., López-Buesa, P. :
The effects of two alleles of IGF2 on fat content in pig carcasses and pork. Meat Sci 90:309-13, 2012. Pubmed reference: 21907500. DOI: 10.1016/j.meatsci.2011.07.016.
2011 Boysen, T.J., Tetens, J., Thaller, G. :
Evidence for additional functional genetic variation within the porcine IGF2 gene affecting body composition traits in an experimental Piétrain × Large White/Landrace cross. Animal 5:672-7, 2011. Pubmed reference: 22439990. DOI: 10.1017/S1751731110002466.
Braunschweig, M.H., Owczarek-Lipska, M., Stahlberger-Saitbekova, N. :
Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet 12:47, 2011. Pubmed reference: 21575277. DOI: 10.1186/1471-2156-12-47.
2010 Fontanesi, L., Speroni, C., Buttazzoni, L., Scotti, E., Dall'Olio, S., Nanni Costa, L., Davoli, R., Russo, V. :
The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism. J Anim Sci 88:2235-45, 2010. Pubmed reference: 20382874. DOI: 10.2527/jas.2009-2560.
Hou, G., Wang, D., Guan, S., Zeng, H., Huang, X., Ma, Y. :
Associated analysis of single nucleotide polymorphisms of IGF2 gene's exon 8 with growth traits in Wuzhishan pig. Mol Biol Rep 37:497-500, 2010. Pubmed reference: 19701694. DOI: 10.1007/s11033-009-9681-5.
Stinckens, A., Mathur, P., Janssens, S., Bruggeman, V., Onagbesan, O.M., Schroyen, M., Spincemaille, G., Decuypere, E., Georges, M., Buys, N. :
Indirect effect of IGF2 intron3 g.3072G>A mutation on prolificacy in sows. Anim Genet 41:493-8, 2010. Pubmed reference: 20394605. DOI: 10.1111/j.1365-2052.2010.02040.x.
2009 Oczkowicz, M., Tyra, M., Walinowicz, K., Rózycki, M., Rejduch, B. :
Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds. J Appl Genet 50:257-9, 2009. Pubmed reference: 19638682. DOI: 10.1007/BF03195681.
2008 Yu, D.B., He, Z.L., Zhang, W.F., Jia, X.X., Qiu, X.S., Wang, L.Y., Huang, R.H., Liu, H.L. :
[The genetic effects of IGF2 gene intron3 variance in pigs]. Yi Chuan 30:87-93, 2008. Pubmed reference: 18244908. DOI: 10.3724/sp.j.1005.2008.00087.
2003 Van Laere, A.S., Nguyen, M., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A.L., Haley, C.S., Buys, N., Tally, M., Andersson, G., Georges, M., Andersson, L. :
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-6, 2003. Pubmed reference: 14574411. DOI: 10.1038/nature02064.
1999 Nezer, C., Moreau, L., Brouwers, B., Coppieters, W., Detilleux, J., Hanset, R., Karim, L., Kvasz, A., Leroy, P., Georges, M. :
An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat Genet 21:155-6, 1999. Pubmed reference: 9988262. DOI: 10.1038/5935.

Edit History


  • Created by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023
  • Changed by Imke Tammen2 on 08 Apr 2024