OMIA:002467-9823 : Muscle growth, IGF2-related in Sus scrofa (pig)

Categories: Muscle phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 147470 (gene) , 616489 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002467-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Duo, T., Liu, X., Mo, D., Bian, Y., Cai, S., Wang, M., Li, R., Zhu, Q., Tong, X., Liang, Z., Jiang, W., Chen, S., Chen, Y., He, Z. :
Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs. J Anim Sci Biotechnol 14:141, 2023. Pubmed reference: 37919760 . DOI: 10.1186/s40104-023-00930-4.
2021 Wang, D., Pu, Y., Li, Y., Pan, D., Wang, S., Tian, W., Ma, Y., Jiang, L. :
Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs. BMC Genomics 22:593, 2021. Pubmed reference: 34348644 . DOI: 10.1186/s12864-021-07881-y.
2019 Liu, X., Liu, H., Wang, M., Li, R., Zeng, J., Mo, D., Cong, P., Liu, X., Chen, Y., He, Z. :
Disruption of the ZBED6 binding site in intron 3 of IGF2 by CRISPR/Cas9 leads to enhanced muscle development in Liang Guang Small Spotted pigs. Transgenic Res 28:141-150, 2019. Pubmed reference: 30488155 . DOI: 10.1007/s11248-018-0107-9.
2018 Xiang, G., Ren, J., Hai, T., Fu, R., Yu, D., Wang, J., Li, W., Wang, H., Zhou, Q. :
Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs. Cell Mol Life Sci 75:4619-4628, 2018. Pubmed reference: 30259067 . DOI: 10.1007/s00018-018-2917-6.
2012 Aslan, O., Hamill, R.M., Davey, G., McBryan, J., Mullen, A.M., Gispert, M., Sweeney, T. :
Variation in the IGF2 gene promoter region is associated with intramuscular fat content in porcine skeletal muscle. Mol Biol Rep 39:4101-10, 2012. Pubmed reference: 21779802 . DOI: 10.1007/s11033-011-1192-5.
Burgos, C., Galve, A., Moreno, C., Altarriba, J., Reina, R., García, C., López-Buesa, P. :
The effects of two alleles of IGF2 on fat content in pig carcasses and pork. Meat Sci 90:309-13, 2012. Pubmed reference: 21907500 . DOI: 10.1016/j.meatsci.2011.07.016.
2011 Boysen, T.J., Tetens, J., Thaller, G. :
Evidence for additional functional genetic variation within the porcine IGF2 gene affecting body composition traits in an experimental Piétrain × Large White/Landrace cross. Animal 5:672-7, 2011. Pubmed reference: 22439990 . DOI: 10.1017/S1751731110002466.
Braunschweig, M.H., Owczarek-Lipska, M., Stahlberger-Saitbekova, N. :
Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2. BMC Genet 12:47, 2011. Pubmed reference: 21575277 . DOI: 10.1186/1471-2156-12-47.
2010 Fontanesi, L., Speroni, C., Buttazzoni, L., Scotti, E., Dall'Olio, S., Nanni Costa, L., Davoli, R., Russo, V. :
The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism. J Anim Sci 88:2235-45, 2010. Pubmed reference: 20382874 . DOI: 10.2527/jas.2009-2560.
Hou, G., Wang, D., Guan, S., Zeng, H., Huang, X., Ma, Y. :
Associated analysis of single nucleotide polymorphisms of IGF2 gene's exon 8 with growth traits in Wuzhishan pig. Mol Biol Rep 37:497-500, 2010. Pubmed reference: 19701694 . DOI: 10.1007/s11033-009-9681-5.
Stinckens, A., Mathur, P., Janssens, S., Bruggeman, V., Onagbesan, O.M., Schroyen, M., Spincemaille, G., Decuypere, E., Georges, M., Buys, N. :
Indirect effect of IGF2 intron3 g.3072G>A mutation on prolificacy in sows. Anim Genet 41:493-8, 2010. Pubmed reference: 20394605 . DOI: 10.1111/j.1365-2052.2010.02040.x.
2009 Oczkowicz, M., Tyra, M., Walinowicz, K., Rózycki, M., Rejduch, B. :
Known mutation (A3072G) in intron 3 of the IGF2 gene is associated with growth and carcass composition in Polish pig breeds. J Appl Genet 50:257-9, 2009. Pubmed reference: 19638682 . DOI: 10.1007/BF03195681.
2008 Yu, D.B., He, Z.L., Zhang, W.F., Jia, X.X., Qiu, X.S., Wang, L.Y., Huang, R.H., Liu, H.L. :
[The genetic effects of IGF2 gene intron3 variance in pigs]. Yi Chuan 30:87-93, 2008. Pubmed reference: 18244908 .
2003 Van Laere, A.S., Nguyen, M., Braunschweig, M., Nezer, C., Collette, C., Moreau, L., Archibald, A.L., Haley, C.S., Buys, N., Tally, M., Andersson, G., Georges, M., Andersson, L. :
A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig. Nature 425:832-6, 2003. Pubmed reference: 14574411 . DOI: 10.1038/nature02064.
1999 Nezer, C., Moreau, L., Brouwers, B., Coppieters, W., Detilleux, J., Hanset, R., Karim, L., Kvasz, A., Leroy, P., Georges, M. :
An imprinted QTL with major effect on muscle mass and fat deposition maps to the IGF2 locus in pigs. Nat Genet 21:155-6, 1999. Pubmed reference: 9988262 . DOI: 10.1038/5935.

Edit History

  • Created by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 03 Nov 2021
  • Changed by Imke Tammen2 on 11 Jan 2022