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OMIA:002495-9823 : Polyunsaturated fatty acid ratio in Sus scrofa (pig)

Categories: Adipose tissue phene

Possibly relevant human trait(s) and/or gene(s) (MIM number): 147440 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: You et al. (2021): "pigs were genetically modified with multiple genes that were precisely inserted into the pRosa26 locus by using the clustered regularly spaced short palindrome repeat sequence (CRISPR)/CRISPR-related 9 (Cas9) system and somatic cell nuclear transfer technology (SCNT) in combination. Single copies of the Fat-1 and IGF-1 genes were expressed satisfactorily in various tissues of F0-generation pigs. Importantly, gas chromatography analysis revealed a significantly increased n-3 polyunsaturated fatty acid (PUFA) level in these genetically modified pigs, which led to a significant decrease of the n-6 PUFA/n-3 PUFA ratio from 6.982 to 3.122 (*** p < 0.001)." This phene includes references to studies involving genetically modified organisms (GMO).

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002495-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 You, W., Li, M., Qi, Y., Wang, Y., Chen, Y., Liu, Y., Li, L., Ouyang, H., Pang, D. :
CRISPR/Cas9-mediated specific integration of Fat-1 and IGF-1 at the pRosa26 locus. Genes (Basel) 12:1027, 2021. Pubmed reference: 34356043. DOI: 10.3390/genes12071027.

Edit History


  • Created by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023