OMIA:002495-9823 : Polyunsaturated fatty acid ratio in Sus scrofa (pig)
Categories: Adipose tissue phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 147440 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Species-specific description: You et al. (2021): "pigs were genetically modified with multiple genes that were precisely inserted into the pRosa26 locus by using the clustered regularly spaced short palindrome repeat sequence (CRISPR)/CRISPR-related 9 (Cas9) system and somatic cell nuclear transfer technology (SCNT) in combination. Single copies of the Fat-1 and IGF-1 genes were expressed satisfactorily in various tissues of F0-generation pigs. Importantly, gas chromatography analysis revealed a significantly increased n-3 polyunsaturated fatty acid (PUFA) level in these genetically modified pigs, which led to a significant decrease of the n-6 PUFA/n-3 PUFA ratio from 6.982 to 3.122 (*** p < 0.001)."
This phene includes references to studies involving genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2022||Tu, C.F., Chuang, C.K., Yang, T.S. :|
|The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.|
|2021||You, W., Li, M., Qi, Y., Wang, Y., Chen, Y., Liu, Y., Li, L., Ouyang, H., Pang, D. :|
|CRISPR/Cas9-mediated specific integration of Fat-1 and IGF-1 at the pRosa26 locus. Genes (Basel) 12:1027, 2021. Pubmed reference: 34356043. DOI: 10.3390/genes12071027.|
- Created by Imke Tammen2 on 11 Jan 2022
- Changed by Imke Tammen2 on 11 Jan 2022