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OMIA:002496-9823 : Intramuscular fat, PPARG-related in Sus scrofa (pig)

Categories: Adipose tissue phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601487 (gene)

Mendelian trait/disorder: yes

Disease-related: no

Key variant known: no

Species-specific description: Gu et al. (2021) "generated muscle-specific overexpression of PPARγ [PPARG] in two pig models by random insertion and CRISPR/Cas9 transgenic cloning procedures. The content of intramuscular fat was significantly increased in PPARγ pigs while [the genome editing] had no changes on lean meat ratio." This phene includes references to studies involving genome edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PPARG peroxisome proliferator-activated receptor gamma Sus scrofa 13 NC_010455.5 (68301566..68433951) PPARG Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002496-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2022 Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Gu, H., Zhou, Y., Yang, J., Li, J., Peng, Y., Zhang, X., Miao, Y., Jiang, W., Bu, G., Hou, L., Li, T., Zhang, L., Xia, X., Ma, Z., Xiong, Y., Zuo, B. :
Targeted overexpression of PPARγ in skeletal muscle by random insertion and CRISPR/Cas9 transgenic pig cloning enhances oxidative fiber formation and intramuscular fat deposition. FASEB J 35:e21308, 2021. Pubmed reference: 33481304. DOI: 10.1096/fj.202001812RR.

Edit History


  • Created by Imke Tammen2 on 11 Jan 2022
  • Changed by Imke Tammen2 on 18 Dec 2023