OMIA 002571-9823 : 5-Hydroxytryptamine deficiency in Sus scrofa

Possibly relevant human trait(s) and/or gene(s) (MIM number): 607478 (gene)

Mendelian trait/disorder: yes

Considered a defect: yes

Key variant known: no

Species-specific name: 5-HT deficiency

Species-specific description: Li et al. (2017) used CRISPR/Cas9 technology to create 10 TPH2 targeted piglets. "These Tph2 KO piglets were viable and appeared normal at the birth. However, their central 5-HT levels were dramatically reduced, and their survival and growth rates were impaired before weaning."

This study involves genetically modified organisms (GMO).

Breed: Bama miniature.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
TPH2 tryptophan hydroxylase 2 Sus scrofa 5 NC_010447.5 (35917159..36016981) TPH2 Homologene, Ensembl, NCBI gene

Reference


2017 Li, Z., Yang, H.Y., Wang, Y., Zhang, M.L., Liu, X.R., Xiong, Q., Zhang, L.N., Jin, Y., Mou, L.S., Liu, Y., Li, R.F., Rao, Y., Dai, Y.F. :
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting. J Biomed Res 31:445-452, 2017. Pubmed reference: 28866660. DOI: 10.7555/JBR.31.20170026.

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  • Created by Imke Tammen2 on 12 Sep 2022