OMIA:002586-9695 : Lymphoma, B-cell, susceptibility to in Panthera tigris sumatrae (Sumatran tiger) |
In other species: dog , taurine cattle , indicine cattle (zebu)
Categories: Neoplasm , Haematopoietic system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 151430 (trait) , 603517 (trait) , 151441 (trait) , 601406 (trait)
Mendelian trait/disorder: unknown
Disease-related: yes
Species-specific description: Krol et al. (2020) reported B-cell lymphoma in two related Sumatran tigers. “The finding of such an unusual neoplasm in a male tiger and its male offspring was noteworthy, raising the possibility of a genetic predisposition for this lymphoma type.” (Compiled by Natalia Denisse Ramos Reyes 7/11/2022)
Clinical features: Two tigers which experienced "weeks of ongoing malaise, weight loss, and anorexia” were investigated. "Complete blood counts revealed leukopenia and anemia ... . Splenomegaly was identified on abdominal ultrasonography." ((Krol et al., 2020)
Pathology: Krol et al. (2020): "Cytologic examination and immunohistochemical staining of splenic samples confirmed intermediate to large B-cell lymphoma."
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2022). OMIA:002586-9695: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2020 | Krol, L., Vernau, W., Mutlow, A.G., Brady, S.M., Wack, R.F., Kubly, S., Zwingenberger, A.L., Culp, W.T.N., Palm, C., Rebhun, R.B. : |
| Unusual splenic B-cell lymphoma in two related Sumatran tigers (<i>Panthera tigris sumatrae</i>). J Am Vet Med Assoc 257:1288-1293, 2020. Pubmed reference: 33269968. DOI: 10.2460/javma.257.12.1288. |
Edit History
- Created by Imke Tammen2 on 07 Nov 2022
- Changed by Imke Tammen2 on 07 Nov 2022