In other species: dog , taurine cattle , indicine cattle (zebu)

Categories: Neoplasm , Haematopoietic system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151430 (trait) , 603517 (trait) , 151441 (trait) , 601406 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Krol et al. (2020) reported B-cell lymphoma in two related Sumatran tigers. “The finding of such an unusual neoplasm in a male tiger and its male offspring was noteworthy, raising the possibility of a genetic predisposition for this lymphoma type.” (Compiled by Natalia Denisse Ramos Reyes 7/11/2022)

Genetic engineering: Unknown
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: Two tigers which experienced "weeks of ongoing malaise, weight loss, and anorexia” were investigated. "Complete blood counts revealed leukopenia and anemia ... . Splenomegaly was identified on abdominal ultrasonography." ((Krol et al., 2020)

Pathology: Krol et al. (2020): "Cytologic examination and immunohistochemical staining of splenic samples confirmed intermediate to large B-cell lymphoma."