OMIA:002586-9695 : Lymphoma, B-cell, susceptibility to in Panthera tigris sumatrae
In other species: zebu
Categories: Neoplasm , Haematopoietic system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151430 (trait) , 603517 (trait) , 151441 (trait) , 601406 (trait)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: yes
Species-specific description: Krol et al. (2020) reported B-cell lymphoma in two related Sumatran tigers. “The finding of such an unusual neoplasm in a male tiger and its male offspring was noteworthy, raising the possibility of a genetic predisposition for this lymphoma type.” (Compiled by Natalia Denisse Ramos Reyes 7/11/2022)
Clinical features: Two tigers which experienced "weeks of ongoing malaise, weight loss, and anorexia” were investigated. "Complete blood counts revealed leukopenia and anemia ... . Splenomegaly was identified on abdominal ultrasonography." ((Krol et al., 2020)
Pathology: Krol et al. (2020): "Cytologic examination and immunohistochemical staining of splenic samples confirmed intermediate to large B-cell lymphoma."
|2020||Krol, L., Vernau, W., Mutlow, A.G., Brady, S.M., Wack, R.F., Kubly, S., Zwingenberger, A.L., Culp, W.T.N., Palm, C., Rebhun, R.B. :|
|Unusual splenic B-cell lymphoma in two related Sumatran tigers (<i>Panthera tigris sumatrae</i>). J Am Vet Med Assoc 257:1288-1293, 2020. Pubmed reference: 33269968 . DOI: 10.2460/javma.257.12.1288.|
- Changed by Imke Tammen2 on 07 Nov 2022
- Created by Imke Tammen2 on 07 Nov 2022