OMIA 002586-9695 : Lymphoma, B-cell, susceptibility to in Panthera tigris sumatrae

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 151430 (trait) , 603517 (trait) , 151441 (trait) , 601406 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific description: Krol et al. (2020) reported B-cell lymphoma in two related Sumatran tigers. “The finding of such an unusual neoplasm in a male tiger and its male offspring was noteworthy, raising the possibility of a genetic predisposition for this lymphoma type.” (Compiled by Natalia Denisse Ramos Reyes 7/11/2022)

Clinical features: Two tigers which experienced "weeks of ongoing malaise, weight loss, and anorexia” were investigated. "Complete blood counts revealed leukopenia and anemia ... . Splenomegaly was identified on abdominal ultrasonography." ((Krol et al., 2020)

Pathology: Krol et al. (2020): "Cytologic examination and immunohistochemical staining of splenic samples confirmed intermediate to large B-cell lymphoma."

Reference


2020 Krol, L., Vernau, W., Mutlow, A.G., Brady, S.M., Wack, R.F., Kubly, S., Zwingenberger, A.L., Culp, W.T.N., Palm, C., Rebhun, R.B. :
Unusual splenic B-cell lymphoma in two related Sumatran tigers (<i>Panthera tigris sumatrae</i>). J Am Vet Med Assoc 257:1288-1293, 2020. Pubmed reference: 33269968. DOI: 10.2460/javma.257.12.1288.

Edit History


  • Created by Imke Tammen2 on 07 Nov 2022
  • Changed by Imke Tammen2 on 07 Nov 2022