In other species: Nile tilapia , Tasmanian devil , middle-African hedgehog , African hunting dog , giant panda , domestic cat , elephants , Grevy's zebra , domestic horse , pig , Arabian camel , giraffe , taurine cattle , rabbit , golden hamster , domestic guinea pig , naked mole-rat , bowhead whale , alpaca , gray mouse lemur , long-tailed chinchilla , koala , fishing cat , maned wolf , Amur leopard cat , southern giant pouched rat

Categories: Neoplasm

Single-gene trait/disorder: no

Disease-related: yes

Key variant known: no

Cross-species summary: Renamed [8/7/2023] from 'cancer, generic'. This phene includes information about benign (not cancer) or malignant (cancer) neoplasm that may or may not have a genetic predisposition.

Molecular basis: Rodrigues et al. (2023): "we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types ... . We discovered [somatic] mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers. As in human cancer, TP53 is the most commonly mutated gene, detected in 22.5% of canine tumors overall. Canine tumors share mutational hotspots with human tumors in oncogenes including PIK3CA, KRAS, NRAS, BRAF, KIT and EGFR. Hotspot mutations with significant association to tumor type include NRAS G61R and PIK3CA H1047R in hemangiosarcoma, ERBB2 V659E in pulmonary carcinoma, and BRAF V588E (equivalent of V600E in humans) in urothelial carcinoma."