OMIA:002593-9685 : Cat allergen in Felis catus (domestic cat) |
Categories: Normal phene
Single-gene trait/disorder: yes
Disease-related: no
Key variant known: yes
Year key variant first reported: 2024
Species-specific description:
Brackett et al. (2022) "present a bioinformatics analysis of the major cat allergen, Fel d 1, and demonstrate proof of principle for CRISPR gene editing of the allergen." This study involves in vitro CRISPR gene editing (GMO).
Lee et al. (2024) "generated Fel d 1 chain 2 (CH2) genome-edited cats using the CRISPR-Cas9 system ... . ... ELISA showed that the level of Fel d 1 in the CH2 homozygous genome-edited cat ... was extremely low compared with that in wild type domestic cats ... .
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: The cat allergen causes disease in some humans.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| CH2 | major allergen I, polypeptide chain 2 | Felis catus | E2 | NC_058382.1 (18601998..18599769) | CH2 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002593-9685: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | An, W., Li, T., Tian, X., Fu, X., Li, C., Wang, Z., Wang, J., Wang, X. : |
| Allergies to allergens from cats and dogs: A review and update on sources, pathogenesis, and strategies. Int J Mol Sci 25:10520, 2024. Pubmed reference: 39408849. DOI: 10.3390/ijms251910520. | |
| Cleveland, C.W., Davis, B.W., Khatri, K., Pomés, A., Chapman, M.D., Brackett, N.F. : | |
| Genetic diversity of the major cat allergen, Fel d 1. PNAS Nexus 3:pgae447, 2024. Pubmed reference: 39600803. DOI: 10.1093/pnasnexus/pgae447. | |
| Hilger, C., Janssen-Weets, B., Swiontek, K. : | |
| Hypoallergenic animals: A promise of hope for allergic patients? Allergol Select 8:64-69, 2024. Pubmed reference: 38549813. DOI: 10.5414/ALX02454E. | |
| Lee, S.R., Lee, K.L., Song, S.H., Joo, M.D., Lee, S.H., Kang, J.S., Kang, S.M., Idrees, M., Kim, J.W., Kong, I.K. : | |
| Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system. Sci Rep 14:4987, 2024. Pubmed reference: 38424152. DOI: 10.1038/s41598-024-55464-0. | |
| 2023 | Bergmann, K.C., Raab, J., Graessel, A., Zwingers, T., Becker, S., Kugler, S., Zuberbier, T., Roth-Walter, F., Kramer, M.F., Jensen-Jarolim, E. : |
| The holo beta-lactoglobulin lozenge reduces symptoms in cat allergy-Evaluation in an allergen exposure chamber and by titrated nasal allergen challenge. Clin Transl Allergy 13:e12274, 2023. Pubmed reference: 37488734. DOI: 10.1002/clt2.12274. | |
| Trifonova, D., Curin, M., Riabova, K., Karsonova, A., Keller, W., Grönlund, H., Käck, U., Konradsen, J.R., van Hage, M., Karaulov, A., Valenta, R. : | |
| Allergenic activity of individual cat allergen molecules. Int J Mol Sci 24:16729, 2023. Pubmed reference: 38069052. DOI: 10.3390/ijms242316729. | |
| 2022 | Brackett, N.F., Davis, B.W., Adli, M., Pomés, A., Chapman, M.D. : |
| Evolutionary biology and gene editing of cat allergen, Fel d 1. CRISPR J 5:213-223, 2022. Pubmed reference: 35343817. DOI: 10.1089/crispr.2021.0101. | |
| Hossenbaccus, L., Linton, S., Ramchandani, R., Burrows, A.G., Ellis, A.K. : | |
| Study of cat allergy using controlled methodology-A review of the literature and a call to action. Front Allergy 3:828091, 2022. Pubmed reference: 35386639. DOI: 10.3389/falgy.2022.828091. | |
| Lyons, L.A. : | |
| It's a knockout for cat allergies? CRISPR J 5:356-357, 2022. Pubmed reference: 35686981. DOI: 10.1089/crispr.2022.29148.lal. | |
| 2014 | Nilsson, O.B., van Hage, M., Grönlund, H. : |
| Mammalian-derived respiratory allergens - implications for diagnosis and therapy of individuals allergic to furry animals. Methods 66:S1046-2023(13)00362-9:86-95, 2014. Pubmed reference: 24041755. DOI: 10.1016/j.ymeth.2013.09.002. | |
| 2011 | Niespodziana, K., Focke-Tejkl, M., Linhart, B., Civaj, V., Blatt, K., Valent, P., van Hage, M., Grönlund, H., Valenta, R. : |
| A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J Allergy Clin Immunol 127:1562-70.e6, 2011. Pubmed reference: 21411130. DOI: 10.1016/j.jaci.2011.02.004. | |
| 2010 | Grönlund, H., Saarne, T., Gafvelin, G., van Hage, M. : |
| The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol 151:265-74, 2010. Pubmed reference: 19844127. DOI: 10.1159/000250435. | |
| 2004 | Smith, W., Butler, A.J., Hazell, L.A., Chapman, M.D., Pomés, A., Nickels, D.G., Thomas, W.R. : |
| Fel d 4, a cat lipocalin allergen. Clin Exp Allergy 34:1732-8, 2004. Pubmed reference: 15544598. DOI: 10.1111/j.1365-2222.2004.02090.x. | |
| 2003 | Grönlund, H., Bergman, T., Sandström, K., Alvelius, G., Reininger, R., Verdino, P., Hauswirth, A., Liderot, K., Valent, P., Spitzauer, S., Keller, W., Valenta, R., van Hage-Hamsten, M. : |
| Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. J Biol Chem 278:40144-51, 2003. Pubmed reference: 12732623. DOI: 10.1074/jbc.M301416200. | |
| Liccardi, G., D'Amato, G., Russo, M., Canonica, G.W., D'Amato, L., De Martino, M., Passalacqua, G. : | |
| Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies. Int Arch Allergy Immunol 132:1-12, 2003. Pubmed reference: 14555853. DOI: 10.1159/000073259. |
Edit History
- Created by Imke Tammen2 on 15 Nov 2022
- Changed by Imke Tammen2 on 15 Nov 2022
- Changed by Imke Tammen2 on 18 Dec 2023
- Changed by Imke Tammen2 on 08 Apr 2024