OMIA 002593-9685 : Cat allergen in Felis catus

Category: Normal phene

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Species-specific description: Brackett et al. (2022) "present a bioinformatics analysis of the major cat allergen, Fel d 1, and demonstrate proof of principle for CRISPR gene editing of the allergen."

This study involves in vitro CRISPR gene editing (GMO).

Clinical features: The cat allergen causes disease in some humans.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
CH2 major allergen I, polypeptide chain 2 Felis catus E2 NC_058382.1 (18601998..18599769) CH2 Homologene, Ensembl, NCBI gene


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year. > > > > > > >
2022 Brackett, N.F., Davis, B.W., Adli, M., Pomés, A., Chapman, M.D. :
Evolutionary biology and gene editing of cat allergen, Fel d 1. CRISPR J 5:213-223, 2022. Pubmed reference: 35343817. DOI: 10.1089/crispr.2021.0101.
Lyons, L.A. :
It's a knockout for cat allergies? CRISPR J 5:356-357, 2022. Pubmed reference: 35686981. DOI: 10.1089/crispr.2022.29148.lal.
2011 Niespodziana, K., Focke-Tejkl, M., Linhart, B., Civaj, V., Blatt, K., Valent, P., van Hage, M., Grönlund, H., Valenta, R. :
A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J Allergy Clin Immunol 127:1562-70.e6, 2011. Pubmed reference: 21411130. DOI: 10.1016/j.jaci.2011.02.004.
2010 Grönlund, H., Saarne, T., Gafvelin, G., van Hage, M. :
The major cat allergen, Fel d 1, in diagnosis and therapy. Int Arch Allergy Immunol 151:265-74, 2010. Pubmed reference: 19844127. DOI: 10.1159/000250435.
2004 Smith, W., Butler, A.J., Hazell, L.A., Chapman, M.D., Pomés, A., Nickels, D.G., Thomas, W.R. :
Fel d 4, a cat lipocalin allergen. Clin Exp Allergy 34:1732-8, 2004. Pubmed reference: 15544598. DOI: 10.1111/j.1365-2222.2004.02090.x.
2003 Grönlund, H., Bergman, T., Sandström, K., Alvelius, G., Reininger, R., Verdino, P., Hauswirth, A., Liderot, K., Valent, P., Spitzauer, S., Keller, W., Valenta, R., van Hage-Hamsten, M. :
Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli. J Biol Chem 278:40144-51, 2003. Pubmed reference: 12732623. DOI: 10.1074/jbc.M301416200.
Liccardi, G., D'Amato, G., Russo, M., Canonica, G.W., D'Amato, L., De Martino, M., Passalacqua, G. :
Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies. Int Arch Allergy Immunol 132:1-12, 2003. Pubmed reference: 14555853. DOI: 10.1159/000073259.

Edit History

  • Created by Imke Tammen2 on 15 Nov 2022
  • Changed by Imke Tammen2 on 15 Nov 2022