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OMIA:002622-9031 : Adiponectin enriched eggs in Gallus gallus (chicken)

Categories: Homeostasis / metabolism phene

Mendelian trait/disorder: unknown

Disease-related: no

Species-specific description: Kim et al. (2023): "Adiponectin (ADPN), a hormone derived from adipose tissue, is a potential therapeutic agent for insulin resistance. ... Therefore, in this study, a gene-targeted chicken model was produced in which the gene encoding human ADPN was inserted into Ovalbumin (OVA) using the CRISPR/Cas9 system, and the characteristics of the resulting recombinant ADPN protein were evaluated. As a result, human ADPN was expressed in G1 hen oviducts and egg whites of OVA ADPN knock-in (KI) chickens." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:002622-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

Reference

2022 Kim, Y.M., Park, J.S., Choi, H.J., Jung, K.M., Lee, K.Y., Shim, J.H., Park, K.J., Han, J.Y. :
Efficient production of recombinant human adiponectin in egg white using genome edited chickens. Front Nutr 9:1068558, 2022. Pubmed reference: 36761986. DOI: 10.3389/fnut.2022.1068558.

Edit History


  • Created by Imke Tammen2 on 16 Feb 2023
  • Changed by Imke Tammen2 on 18 Dec 2023