OMIA:002650-9031 : Egg allergen in Gallus gallus (chicken)
Categories: Normal phene
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Year key variant first reported: 2023
Species-specific description: Ezaki et al. (2023) report the development of low-allergen eggs by knock out via genome editing of a major egg allergen, ovomucoid (OVM): " we examined the presence or absence of mutant protein expression, vector sequence insertion, and off-target effects in chickens knocked out with OVM by platinum TALENs. The eggs laid by homozygous OVM-knockout hens showed no evident abnormalities, and immunoblotting showed that the albumen contained neither the mature OVM variant nor the OVM truncated variant. Whole genome sequencing (WGS) revealed that the potential TALEN-induced off-target effects in OVM-knockout chickens were localized in the intergenic and intron regions. The WGS information confirmed that plasmid vectors used for genome editing were only transiently present and did not integrate into the genome of edited chickens."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Have human generated variants been created, e.g. through genetic engineering and gene editing
Clinical features: Egg allergens can cause disease in some humans.
Cite this entry
|2023||Ezaki, R., Sakuma, T., Kodama, D., Sasahara, R., Shiraogawa, T., Ichikawa, K., Matsuzaki, M., Handa, A., Yamamoto, T., Horiuchi, H. :|
|Transcription activator-like effector nuclease-mediated deletion safely eliminates the major egg allergen ovomucoid in chickens. Food Chem Toxicol :113703, 2023. Pubmed reference: 36889429. DOI: 10.1016/j.fct.2023.113703.|
- Created by Imke Tammen2 on 10 Mar 2023