Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606131 (gene)

Mendelian trait/disorder: yes

Disease-related: no

Key variant known: yes

Year key variant first reported: 2023

Species-specific description: Li et al. (2023) "bred F1 generation Murf1+/- and F2 generation Murf1-/- Duroc pigs from F0 Murf1-/- pigs [generated by CRISPR/Cas9 genome editing] to investigate the effect of Murf1 knockout on skeletal muscle development. ... inhibiting muscle protein degradation in MuRF1-deficient Duroc pigs increases the size of their myofibers and their percentage of lean meat without influencing their growth or pork quality." MURF1 is an alternative name for TRIM63. This study involves genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Breed: Duroc (Pig) (VBO_0001127).
Breeds in which the phene has been documented. (If a likely causal variant has been documented for the phene, see the variant table breeds in which the variant has been reported).

Associated gene: