OMIA:002799-9615 : Dog allergen in Canis lupus familiaris (dog) |
Categories: Normal phene
Single-gene trait/disorder: yes
Disease-related: no
Key variant known: no
Cross-species summary: Dog allergens can cause disease in some humans
Molecular basis: Walker et al. (2026): "Using CRISPR-Cas9 editing and somatic cell nuclear transfer, we produced two healthy beagle puppies carrying a frameshift mutation in exon 1 of the Can f 1 [also called OBP2B] gene. Salivary and hair/dander analysis demonstrated the absence of Can f 1 protein in the edited dogs." This study involves gene edited or genetically modified organisms (GMO).
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| OBP2B | odorant binding protein 2B | Canis lupus familiaris | 9 | NC_051813.1 (50582002..50579508) | OBP2B | Ensembl, NCBI gene |
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:002799-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2026 | Walker, M.W.G., Margolis, C., Wiegand, T., Gavin, N., Loewy, E. : |
| Targeted genetic knockout of Can f1, the major allergen in dogs. CRISPR J :25731599261473124, 2026. Pubmed reference: 42554239. DOI: 10.1177/25731599261473124. | |
| 2025 | Gromek, W., Kołdej, N., Kurowski, M., Majsiak, E. : |
| Furry animal allergy: Lipocalins, serum albumins, and secretoglobins-cross-reactivity, diagnosis, and management strategies. Clin Rev Allergy Immunol 68:75, 2025. Pubmed reference: 40739451. DOI: 10.1007/s12016-025-09086-7. | |
| 2024 | An, W., Li, T., Tian, X., Fu, X., Li, C., Wang, Z., Wang, J., Wang, X. : |
| Allergies to allergens from cats and dogs: A review and update on sources, pathogenesis, and strategies. Int J Mol Sci 25:10520, 2024. Pubmed reference: 39408849. DOI: 10.3390/ijms251910520. | |
| Hilger, C., Janssen-Weets, B., Swiontek, K. : | |
| Hypoallergenic animals: A promise of hope for allergic patients? Allergol Select 8:64-69, 2024. Pubmed reference: 38549813. DOI: 10.5414/ALX02454E. | |
| 2023 | Kozlov, E.M., Dubovets, A.A., Ryabova, K.A., Galashin, A.R., Levshina, A.R., Karsonova, A.V., Karaulov, A.V. : |
| Modern concept of molecular diagnostics of allergy to dogs. Bull Exp Biol Med 175:715-719, 2023. Pubmed reference: 37978146. DOI: 10.1007/s10517-023-05932-w. | |
| 2014 | Nilsson, O.B., van Hage, M., Grönlund, H. : |
| Mammalian-derived respiratory allergens - implications for diagnosis and therapy of individuals allergic to furry animals. Methods 66:S1046-2023(13)00362-9:86-95, 2014. Pubmed reference: 24041755. DOI: 10.1016/j.ymeth.2013.09.002. |
Edit History
- Created by Imke Tammen on 21 Nov 2023
- Changed by Imke Tammen on 27 Aug 2024
- Changed by Imke Tammen on 23 Apr 2025
- Changed by Imke Tammen on 10 Aug 2026