OMIA:002812-9823 : LGALS12 deficiency in Sus scrofa (pig) |
Categories: Adipose tissue phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606096 (gene)
Mendelian trait/disorder: yes
Disease-related: no
Key variant known: yes
Year key variant first reported: 2023
Molecular basis: Wu et al. (2023) "used CRISPR/Cas9 to construct porcine fetal fibroblasts (PFFs) with a 43 bp deletion in LGALS12 exon 2. Using these PFFs as donor cells, a LGALS12 knockout pig model was generated via somatic cell nuclear transfer. Primary cultures of porcine intramuscular (IM) and subcutaneous (SC) adipocytes were established using cells from LGALS12 knockout pigs and wild-type pigs. ... Our findings suggest that LGALS12 deficiency affects the adipogenesis of IM and SC adipocytes through different mechanisms." This study involves genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| LGALS12 | galectin 12 | Sus scrofa | 2 | NC_010444.4 (8475360..8454362) | LGALS12 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:002812-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
Reference
| 2023 | Wu, W., Yin, Y., Huang, J., Yang, R., Li, Q., Pan, J., Zhang, J. : |
| CRISPR/Cas9-meditated gene knockout in pigs proves that LGALS12 deficiency suppresses the proliferation and differentiation of porcine adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids 1869:159424, 2023. Pubmed reference: 37956708. DOI: 10.1016/j.bbalip.2023.159424. |
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- Created by Imke Tammen2 on 15 Jan 2024